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Gene Review

hspD  -  heat shock cognate protein

Dictyostelium discoideum AX4

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Disease relevance of hspD

  • To investigate the protein-protein interaction in vitro, we expressed all three polypeptides separately in Escherichia coli and performed reconstitution experiments of complete or truncated hsc70 with the 32 and 34 kDa subunits of the capping protein [1].

High impact information on hspD

  • Viscosity measurements and studies on the polymerization kinetics of pyrene-labeled actin showed that hsc70 increased the capping activity of cap32/34 up to 10-fold, whereas hsc70 alone had no effect on actin polymerization [1].


  1. The heat shock cognate protein from Dictyostelium affects actin polymerization through interaction with the actin-binding protein cap32/34. Haus, U., Trommler, P., Fisher, P.R., Hartmann, H., Lottspeich, F., Noegel, A.A., Schleicher, M. EMBO J. (1993) [Pubmed]
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