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Gene Review:

qacEdelta1 - QacEdelta1 multidrug exporter

Pseudomonas aeruginosa

Mugnier, P. et al., Kazama, H. et al., Naas, T. et al.

Naas, Poirel, Karim, Nordmann,

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Disease relevance of qacEdelta1

We found the qacE delta 1 gene in 36 of 103 strains of Staphylococcus and in nine of 48 strains of Enterococcus [1].
Distribution of the antiseptic-resistance gene qacE delta 1 in gram-positive bacteria [1].

High impact information on qacEdelta1

Cloning and nucleotide sequence analysis revealed the dicistronic arrangement of an aac(6')-Ib variant and a novel blaOXA-type gene between the intI and qacE delta 1 genes typical of integrons, in PAe391, this integron was apparently chromosome-borne [2].
In50 contains within its variable region, in addition to qacE delta 1 and sull genes commonly found in class 1 integrons, two gene cassettes, veb1 and aadB [3].

References

Distribution of the antiseptic-resistance gene qacE delta 1 in gram-positive bacteria. Kazama, H., Hamashima, H., Sasatsu, M., Arai, T. FEMS Microbiol. Lett. (1998) [Pubmed]
Carbapenems as inhibitors of OXA-13, a novel, integron-encoded beta-lactamase in Pseudomonas aeruginosa. Mugnier, P., Podglajen, I., Goldstein, F.W., Collatz, E. Microbiology (Reading, Engl.) (1998) [Pubmed]
Molecular characterization of In50, a class 1 integron encoding the gene for the extended-spectrum beta-lactamase VEB-1 in Pseudomonas aeruginosa. Naas, T., Poirel, L., Karim, A., Nordmann, P. FEMS Microbiol. Lett. (1999) [Pubmed]

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