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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

RSPO2  -  R-spondin 2

Homo sapiens

Synonyms: MGC35555, R-spondin-2, Roof plate-specific spondin-2, UNQ9384/PRO34209, hRspo2
 
 
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High impact information on RSPO2

  • Antisense Morpholino experiments in Xenopus embryos and RNAi experiments in HeLa cells reveal that Rspo2 is required for Wnt/beta-catenin signaling [1].
  • In Xenopus embryos depleted of Rspo2, the muscle markers myoD and myf5 fail to be activated and later muscle development is impaired [1].

References

  1. R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis. Kazanskaya, O., Glinka, A., del Barco Barrantes, I., Stannek, P., Niehrs, C., Wu, W. Dev. Cell (2004) [Pubmed]
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