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Gene Review

GLDN  -  gliomedin

Homo sapiens

Synonyms: CLOM, COLM, CRG-L2, CRGL2, Gliomedin, ...
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Disease relevance of GLDN

  • We present the cloning and characterization of a novel gene, CRG-L2 (Cancer related gene-Liver 2), which displays high expression in murine and human hepatocellular carcinomas [1].

High impact information on GLDN

  • Its restricted expression in normal tissues and unique early upregulation during tumor development make CRG-L2 an excellent candidate as a new clinical marker of HCC [1].
  • Using in situ hybridization, we show that CRG-L2 mRNA levels are increased early during the development of liver tumors in C3H/HeJ mice, and that in normal tissues CRG-L2 mRNA is restricted to the murine testis and human placenta [1].


  1. Identification and characterization of CRG-L2, a new marker for liver tumor development. Graveel, C.R., Harkins-Perry, S.R., Acevedo, L.G., Farnham, P.J. Oncogene (2003) [Pubmed]
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