Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Toll-4 - CG18241 gene product from transcript...

Drosophila melanogaster

Synonyms: CG18241, CT29238, Dmel\CG18241, TL4, Tl-4, ...

Schwartz, Y.B. et al., Shin, S.W. et al., Tauszig, S. et al.

Schwartz, Boykova, Belyaeva, Ashburner, Zhimulev,

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High impact information on Toll-4

Two of these genes, Toll-3 and Toll-4, are expressed at a low level [1].
Spz1C was constitutively expressed in the mosquito fat body, whereas Spz1B and Toll4 were primarily expressed in ovarian tissues of female mosquitoes [2].
A lethal mutation, swit476, shows a severe disruption of the ecdysone pathway and is a C>Y substitution in one of the two conserved CysXCys motifs that are common to SWI and the Drosophila Toll-4 protein [3].

References

Toll-related receptors and the control of antimicrobial peptide expression in Drosophila. Tauszig, S., Jouanguy, E., Hoffmann, J.A., Imler, J.L. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
A Toll Receptor and a Cytokine, Toll5A and Spz1C, Are Involved in Toll Antifungal Immune Signaling in the Mosquito Aedes aegypti. Shin, S.W., Bian, G., Raikhel, A.S. J. Biol. Chem. (2006) [Pubmed]
Molecular characterization of the singed wings locus of Drosophila melanogaster. Schwartz, Y.B., Boykova, T., Belyaeva, E.S., Ashburner, M., Zhimulev, I.F. BMC Genet. (2004) [Pubmed]

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