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Gene Review:

hfw - halfway

Drosophila melanogaster

Synonyms: CG3095, CT10406, Dmel\CG3095, EG:171E4.2, Protein halfway, ...

Kokoza, E.B. et al., Schwartz, Y.B. et al., Cairns, B.R., Belyaeva, E.S. et al.

Schwartz, Boykova, Belyaeva, Ashburner, Zhimulev, Cairns,

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High impact information on hfw

Although all contain the ATPase ISWI, their properties in vitro are markedly different, distinct from SWI-SNF and reveal intriguing connections to both transcription and chromatin assembly [1].
Two other loci dor and swi are situated some to the right of 2B5 [2].
A lethal mutation, swit476, shows a severe disruption of the ecdysone pathway and is a C>Y substitution in one of the two conserved CysXCys motifs that are common to SWI and the Drosophila Toll-4 protein [3].

Biological context of hfw

Genes ecs, dor and swi from this cluster have been mapped in D. funebris, D. virilis, D. hydei, D. repleta, D. mercatorum and D. paranaensis to the telomeric region of the X chromosome, in D. kanekoi to the distal region, and in D. pseudoobscura, to the proximal region of the X chromosome [4].

References

Chromatin remodeling machines: similar motors, ulterior motives. Cairns, B.R. Trends Biochem. Sci. (1998) [Pubmed]
Cytogenetic analysis of the 2B3-4--2B11 region of the X-chromosome of Drosophila melanogaster. I. Cytology of the region and mutant complementation groups. Belyaeva, E.S., Aizenzon, M.G., Semeshin, V.F., Kiss, I.I., Koczka, K., Baritcheva, E.M., Gorelova, T.D., Zhimulev, I.F. Chromosoma (1980) [Pubmed]
Molecular characterization of the singed wings locus of Drosophila melanogaster. Schwartz, Y.B., Boykova, T., Belyaeva, E.S., Ashburner, M., Zhimulev, I.F. BMC Genet. (2004) [Pubmed]
Localization of genes ecs, dor and swi in eight Drosophila species. Kokoza, E.B., Belyaeva, E.S., Zhimulev, I.F. Genetica (1992) [Pubmed]

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