The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Fat Body

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Fat Body


Psychiatry related information on Fat Body


High impact information on Fat Body

  • This involves TSC/TOR signaling in the fat body, and a remote inhibition of organismal growth via local repression of PI3-kinase signaling in peripheral tissues [11].
  • Amino acids and the humoral regulation of growth: fat bodies use slimfast [12].
  • Remarkably, downregulation of slimfast specifically within the fat body causes a global growth defect similar to that seen in Drosophila raised under poor nutritional conditions [11].
  • Estrogen, lipid oxidation, and body fat [13].
  • After one year, the subjects in both intervention groups had reached or closely approached NCEP Step 1 dietary goals and reduced their mean body fat significantly (range of reduction in mean fat weight, 4.0 to 7.8 kg) [14].

Chemical compound and disease context of Fat Body

  • A longitudinal mixed-model regression for weight change controlling for age, race, sex, body mass index, and percent body fat estimated that zonisamide treatment over the 16-week study duration was associated with significantly greater weight loss than was placebo (t = 6.4; P<.001) [15].
  • IMPLICATIONS: Further research should focus on alternative endocrinologic mechanisms for risk associated with obesity and body fat distribution and for the biologic relevance of the increased risk associated with androstenedione in both premenopausal and postmenopausal disease [16].
  • CONCLUSIONS: Body weight, total body fat mass, and proportion of android fat are increased in postmenopausal women with primary hyperparathyroidism; these unexplained factors may be relevant to the increased incidence of cardiovascular disease in this condition [17].
  • During the 4 weeks of parenteral nutrition, body weight, total body fat, and total body potassium, but not total body nitrogen, increased significantly in the study group (p less than 0.001) [18].
  • Since the leptin receptor gene is a candidate gene for obesity, and because of its proximity to D1S198, a marker previously linked to insulin secretion, the LEPR gene was sequenced in 20 non-diabetic Pima Indians chosen for extremes in percent body fat and in their acute insulin response to intravenous glucose [19].

Biological context of Fat Body


Anatomical context of Fat Body

  • Vitellogenins are yolk protein precursors that are synthesised in the liver of lower vertebrates in response to ovarian hormones, and in the fat body tissue of insects, under the influence, in most species, of juvenile hormone (JH) from the corpora allata (CA) [25].
  • The correlation of fat distribution with age, gender, total body fat, energy balance, adipose tissue lipoprotein lipase and lipolytic activity, adipose tissue receptors, and genetic characteristics are discussed [26].
  • Relationship between skeletal muscle insulin resistance, insulin-mediated glucose disposal, and insulin binding. Effects of obesity and body fat topography [27].
  • The genes are strongly expressed in fat body and hemocytes after injection of bacteria, the CecA genes being much more active than CecB in the fat body [28].
  • To determine whether the depletion of body fat caused by adenovirus-induced hyperleptinemia is mediated via the hypothalamus, we used as a "bioassay" for hypothalamic leptin activity the hypothalamic expression of a leptin-regulated peptide, cocaine- and amphetamine-regulated transcript (CART) [29].

Associations of Fat Body with chemical compounds

  • We conclude that HDL2 levels are inversely correlated with truncal fat, plasma insulin levels, and the presence of glucose intolerance and are not independently associated with sex or total body fat [30].
  • In insects, on the other hand, because the CA of adults of both sexes are active, it appeared that male fat body could not normally respond to JH by synthesising vitellogenin [25].
  • Analysis of the fat-reducing gene inactivations in insulin, serotonin and tubby signalling mutants of C. elegans, which have increased body fat, identifies a core set of fat regulatory genes as well as pathway-specific fat regulators [31].
  • Imaginal disks were cultured in a new medium in vitrol Optimal growth occurred when the medium was supplemented with insulin and a juvenile hormone analog and conditioned by larval fat body [32].
  • To determine the relationship between lipid profiles and the type of weight training and to assess the effects of anabolic-androgenic steroids on lipids, bodybuilders and powerlifters of similar age, body fat, and testosterone levels were studied before and after androgen use [33].

Gene context of Fat Body

  • In response to infection, two Rel proteins, Dif and Dorsal, translocate from the cytoplasm to the nuclei of larval fat-body cells [34].
  • Indy was most abundantly expressed in the fat body, midgut, and oenocytes: the principal sites of intermediary metabolism in the fly [35].
  • Suppression of body fat accumulation in myostatin-deficient mice [36].
  • Here we show that a conditional knockout of insulin receptor substrate 2 (Irs2) in mouse pancreas beta cells and parts of the brain--including the hypothalamus--increased appetite, lean and fat body mass, linear growth, and insulin resistance that progressed to diabetes [37].
  • A single copy of the three sites is sufficient to direct the sex and fat body specificities of Yp transcription [38].

Analytical, diagnostic and therapeutic context of Fat Body


  1. Regulation of gonadotropin secretion in Turner's syndrome. Boyar, R.M., Ramsey, J., Chipman, J., Fevre, M., Madden, J., Marks, J. N. Engl. J. Med. (1978) [Pubmed]
  2. Effects of the obese gene product on body weight regulation in ob/ob mice. Pelleymounter, M.A., Cullen, M.J., Baker, M.B., Hecht, R., Winters, D., Boone, T., Collins, F. Science (1995) [Pubmed]
  3. Weight loss in amateur wrestlers and its effect on serum testosterone levels. Strauss, R.H., Lanese, R.R., Malarkey, W.B. JAMA (1985) [Pubmed]
  4. Human adipocyte cholesterol. Concentration, localization, synthesis, and turnover. Schreibman, P.H., Dell, R.B. J. Clin. Invest. (1975) [Pubmed]
  5. Improved insulin sensitivity and resistance to weight gain in mice null for the Ahsg gene. Mathews, S.T., Singh, G.P., Ranalletta, M., Cintron, V.J., Qiang, X., Goustin, A.S., Jen, K.L., Charron, M.J., Jahnen-Dechent, W., Grunberger, G. Diabetes (2002) [Pubmed]
  6. Possible role of adiponectin and insulin sensitivity in mediating the favorable effects of lower body fat mass on blood lipids. Buemann, B., Astrup, A., Pedersen, O., Black, E., Holst, C., Toubro, S., Echwald, S., Holst, J.J., Rasmussen, C., Sørensen, T.I. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  7. Type 2 diabetes and metabolic syndrome in Filipina-American women : a high-risk nonobese population. Araneta, M.R., Wingard, D.L., Barrett-Connor, E. Diabetes Care (2002) [Pubmed]
  8. Leptin in women with eating disorders. Nakai, Y., Hamagaki, S., Kato, S., Seino, Y., Takagi, R., Kurimoto, F. Metab. Clin. Exp. (1999) [Pubmed]
  9. Asthma mortality: another opinion--is it a matter of life and ... bread? Chang, C.C., Phinney, S.D., Halpern, G.M., Gershwin, M.E. The Journal of asthma : official journal of the Association for the Care of Asthma. (1993) [Pubmed]
  10. Waist to hip ratio and psychosocial factors in adults with insulin-dependent diabetes mellitus: the Pittsburgh Epidemiology of Diabetes Complications study. Lloyd,, C.E., Wing, R.R., Orchard, T.J. Metab. Clin. Exp. (1996) [Pubmed]
  11. A nutrient sensor mechanism controls Drosophila growth. Colombani, J., Raisin, S., Pantalacci, S., Radimerski, T., Montagne, J., Léopold, P. Cell (2003) [Pubmed]
  12. Amino acids and the humoral regulation of growth: fat bodies use slimfast. Bradley, G.L., Leevers, S.J. Cell (2003) [Pubmed]
  13. Estrogen, lipid oxidation, and body fat. O'Sullivan, A.J., Hoffman, D.M., Ho, K.K. N. Engl. J. Med. (1995) [Pubmed]
  14. The effects on plasma lipoproteins of a prudent weight-reducing diet, with or without exercise, in overweight men and women. Wood, P.D., Stefanick, M.L., Williams, P.T., Haskell, W.L. N. Engl. J. Med. (1991) [Pubmed]
  15. Zonisamide for weight loss in obese adults: a randomized controlled trial. Gadde, K.M., Franciscy, D.M., Wagner, H.R., Krishnan, K.R. JAMA (2003) [Pubmed]
  16. Case-control study of endogenous steroid hormones and endometrial cancer. Potischman, N., Hoover, R.N., Brinton, L.A., Siiteri, P., Dorgan, J.F., Swanson, C.A., Berman, M.L., Mortel, R., Twiggs, L.B., Barrett, R.J., Wilbanks, G.D., Persky, V., Lurain, J.R. J. Natl. Cancer Inst. (1996) [Pubmed]
  17. Body weight and bone mineral density in postmenopausal women with primary hyperparathyroidism. Grey, A.B., Evans, M.C., Stapleton, J.P., Reid, I.R. Ann. Intern. Med. (1994) [Pubmed]
  18. Changes in body composition in patients with small-cell lung cancer. The effect of total parenteral nutrition as an adjunct to chemotherapy. Shike, M., Russel, D.M., Detsky, A.S., Harrison, J.E., McNeill, K.G., Shepherd, F.A., Feld, R., Evans, W.K., Jeejeebhoy, K.N. Ann. Intern. Med. (1984) [Pubmed]
  19. Structure and sequence variation at the human leptin receptor gene in lean and obese Pima Indians. Thompson, D.B., Ravussin, E., Bennett, P.H., Bogardus, C. Hum. Mol. Genet. (1997) [Pubmed]
  20. Basement membrane polarizes lectin binding sites of Drosophila larval fat body cells. Rizki, T.M., Rizki, R.M. Nature (1983) [Pubmed]
  21. DNA regions that regulate the ovarian transcriptional specificity of Drosophila yolk protein genes. Logan, S.K., Garabedian, M.J., Wensink, P.C. Genes Dev. (1989) [Pubmed]
  22. Imprinting of female offspring with testosterone results in insulin resistance and changes in body fat distribution at adult age in rats. Nilsson, C., Niklasson, M., Eriksson, E., Björntorp, P., Holmäng, A. J. Clin. Invest. (1998) [Pubmed]
  23. Reduced sympathetic nervous activity. A potential mechanism predisposing to body weight gain. Spraul, M., Ravussin, E., Fontvieille, A.M., Rising, R., Larson, D.E., Anderson, E.A. J. Clin. Invest. (1993) [Pubmed]
  24. Insulin sensitivity and body fat distribution in normotensive offspring of hypertensive parents. Allemann, Y., Horber, F.F., Colombo, M., Ferrari, P., Shaw, S., Jaeger, P., Weidmann, P. Lancet (1993) [Pubmed]
  25. Induction of vitellogenin and growth of implanted oocytes in male cockroaches. Mundall, E.C., Tobe, S.S., Stay, B. Nature (1979) [Pubmed]
  26. Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Wajchenberg, B.L. Endocr. Rev. (2000) [Pubmed]
  27. Relationship between skeletal muscle insulin resistance, insulin-mediated glucose disposal, and insulin binding. Effects of obesity and body fat topography. Evans, D.J., Murray, R., Kissebah, A.H. J. Clin. Invest. (1984) [Pubmed]
  28. The immune response in Drosophila: pattern of cecropin expression and biological activity. Samakovlis, C., Kimbrell, D.A., Kylsten, P., Engström, A., Hultmark, D. EMBO J. (1990) [Pubmed]
  29. Comparing the hypothalamic and extrahypothalamic actions of endogenous hyperleptinemia. Wang, Z.W., Zhou, Y.T., Kakuma, T., Lee, Y., Higa, M., Kalra, S.P., Dube, M.G., Kalra, P.S., Unger, R.H. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  30. The ratio of waist-to-hip circumference, plasma insulin level, and glucose intolerance as independent predictors of the HDL2 cholesterol level in older adults. Ostlund, R.E., Staten, M., Kohrt, W.M., Schultz, J., Malley, M. N. Engl. J. Med. (1990) [Pubmed]
  31. Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Ashrafi, K., Chang, F.Y., Watts, J.L., Fraser, A.G., Kamath, R.S., Ahringer, J., Ruvkun, G. Nature (2003) [Pubmed]
  32. In vitro growth of imaginal disks from Drosophila melanogaster. Davis, K.T., Shearn, A. Science (1977) [Pubmed]
  33. High-density-lipoprotein cholesterol in bodybuilders v powerlifters. Negative effects of androgen use. Hurley, B.F., Seals, D.R., Hagberg, J.M., Goldberg, A.C., Ostrove, S.M., Holloszy, J.O., Wiest, W.G., Goldberg, A.P. JAMA (1984) [Pubmed]
  34. Regulated nuclear import of Rel proteins in the Drosophila immune response. Wu, L.P., Anderson, K.V. Nature (1998) [Pubmed]
  35. Extended life-span conferred by cotransporter gene mutations in Drosophila. Rogina, B., Reenan, R.A., Nilsen, S.P., Helfand, S.L. Science (2000) [Pubmed]
  36. Suppression of body fat accumulation in myostatin-deficient mice. McPherron, A.C., Lee, S.J. J. Clin. Invest. (2002) [Pubmed]
  37. Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes. Lin, X., Taguchi, A., Park, S., Kushner, J.A., Li, F., Li, Y., White, M.F. J. Clin. Invest. (2004) [Pubmed]
  38. Three protein binding sites form an enhancer that regulates sex- and fat body-specific transcription of Drosophila yolk protein genes. An, W., Wensink, P.C. EMBO J. (1995) [Pubmed]
  39. Fat body protein granules and storage proteins in the silkmoth, Hyalophora cecropia. Tojo, S., Betchaku, T., Ziccardi, V.J., Wyatt, G.R. J. Cell Biol. (1978) [Pubmed]
  40. Purification and molecular cloning of an inducible gram-negative bacteria-binding protein from the silkworm, Bombyx mori. Lee, W.J., Lee, J.D., Kravchenko, V.V., Ulevitch, R.J., Brey, P.T. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  41. Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy. Chen, G., Koyama, K., Yuan, X., Lee, Y., Zhou, Y.T., O'Doherty, R., Newgard, C.B., Unger, R.H. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  42. Changes in body fat composition after 1 year of salvage therapy with lopinavir/ritonavir-containing regimens and its relationship with lopinavir plasma concentrations. Gutiérrez, F., Padilla, S., Masiá, M., Navarro, A., Gallego, J., Hernández, I., Ramos, J.M., Martin-Hidalgo, A. Antivir. Ther. (Lond.) (2004) [Pubmed]
WikiGenes - Universities