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Gene Review

NOTO  -  notochord homeobox

Homo sapiens

Synonyms: Homeobox protein notochord
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Disease relevance of NOTO

  • The main type of lens opacity was nuclear in the Singapore group and cortical in the Noto and Icelandic groups [1].

High impact information on NOTO

  • The (228)Ra/(226)Ra ratio of coastal water from all sites around Noto Peninsula shows seasonal variation, with minimum values during summer ((228)Ra/(226)Ra=0.7) and maximum values during autumn-winter ((228)Ra/(226)Ra=1.7-2) [2].

Analytical, diagnostic and therapeutic context of NOTO

  • In this study, low-background gamma-spectrometry was used to determine the (228)Ra/(226)Ra ratio of 131 coastal water samples from various environments around Honshu Island, Japan (mainly around Noto Peninsula) at 1-3 month intervals from April 2003 until September 2005 [2].
  • Ultrasonography showed a left renal mass and the patient was referred to Noto General Hospital for urological evaluation [3].


  1. High prevalence of nuclear cataract in the population of tropical and subtropical areas. Sasaki, H., Jonasson, F., Shui, Y.B., Kojima, M., Ono, M., Katoh, N., Cheng, H.M., Takahashi, N., Sasaki, K. Developments in ophthalmology. (2002) [Pubmed]
  2. Seasonal variations in 228Ra/226Ra ratio within coastal waters of the Sea of Japan: implications for water circulation patterns in coastal areas. Inoue, M., Tanaka, K., Watanabe, S., Kofuji, H., Yamamoto, M., Komura, K. Journal of environmental radioactivity. (2006) [Pubmed]
  3. Case of leiomyosarcoma of the renal pelvis. Minami, H., Ueki, O., Tanaka, T., Nishida, H., Hashimoto, T., Kawaguchi, K. International journal of urology : official journal of the Japanese Urological Association. (2004) [Pubmed]
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