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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

IFNA6  -  interferon, alpha 6

Homo sapiens

Synonyms: IFN-alpha-6, IFN-alphaK, Interferon alpha-54, Interferon alpha-6, Interferon alpha-K, ...
 
 
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Disease relevance of IFNA6

  • IFN subtypes differentially regulated the onset of erythroleukemia with delayed onset and increased survival, possibly via a reduction in cell viability, and enhanced antiproliferative and apoptotic effects observed for IFNA6 and IFNA9 treatment, respectively [1].
  • However, the recombinant beta interferons inhibited cytomegalovirus more than either the native beta or the alpha interferon species with the exception of interferon alpha K (alpha 6) [2].
 

High impact information on IFNA6

  • Although interferon beta, produced by recombinant DNA technology and purified to homogeneity, was not equivalent in effectiveness to naturally produced interferon beta, its antiproliferative activity was greater than interferon alpha 54 for 3 of 4 cell lines tested [3].

References

  1. Type I interferon differential therapy for erythroleukemia: specificity of STAT activation. Cull, V.S., Tilbrook, P.A., Bartlett, E.J., Brekalo, N.L., James, C.M. Blood (2003) [Pubmed]
  2. Comparison of antiviral activities of cloned and native human interferons against herpes simplex virus types 1 and 2 and human cytomegalovirus. Rasmussen, L.E., Chen, P.T., Merigan, T.C. Antimicrob. Agents Chemother. (1984) [Pubmed]
  3. Antiproliferative activities of interferons against human bladder carcinoma cell lines in vitro. Borden, E.C., Groveman, D.S., Nasu, T., Reznikoff, C., Bryan, G.T. J. Urol. (1984) [Pubmed]
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