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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Cell Survival

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Disease relevance of Cell Survival


Psychiatry related information on Cell Survival


High impact information on Cell Survival

  • The mechanism by which Bcl-2 promotes cell survival remains unknown, but it appears to require association with Bax [8].
  • The proinflammatory cytokine tumor necrosis factor (TNF) alpha signals both cell survival and death [9].
  • In contrast to measurements of aging for mitotic cells, cell survival in the nonmitotic state is decreased by Sir2 activity under conditions that mimic calorie restriction [10].
  • Nuclear exclusion of the forkhead transcription factor FOXO3a by protein kinase Akt contributes to cell survival [11].
  • Thus, we have elucidated an integrin-controlled pathway that is, at least in part, responsible for the cell survival effects of cell-ECM interactions [12].

Chemical compound and disease context of Cell Survival


Biological context of Cell Survival


Anatomical context of Cell Survival

  • Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress [22].
  • SPP induces the Gi/mitogen-activated protein kinase/cell survival pathway and the small GTPase Rho- and Raccoupled adherens junction assembly [23].
  • Altogether, our findings have important implications for the role of hypoxic response and HIF-1alpha in development, and in cell survival in tissues challenged by interruption of vascular flow; they also illustrate the complexities of HIF-1alpha response in vivo, and they provide new insights into mechanisms of growth plate development [24].
  • Bcl-2 overexpression in mitochondria suppresses the release of these proapoptotic molecules, resulting in cell survival despite partial procaspase processing by granzyme B [25].
  • In the present study, we show that cross-linking of OX40L on CD40L-stimulated B cells, alpha IgD dextran-stimulated B cells, or both results in a significantly enhanced proliferative response with no change in the cell survival rate [26].

Associations of Cell Survival with chemical compounds

  • Control experiments showed that taxol did not simply affect uptake of nucleotides, glucose or amino acids, nor did it nonspecifically affect protein synthesis, cell morphology or cell viability [27].
  • Transcription is blocked by pyrimidine dimers in template DNA and the selective removal of these lesions seems to be important for cell survival after irradiation with ultraviolet light [28].
  • Neonatal administration of allopregnanolone delays the onset of neurological symptoms, increases Purkinje and granule cell survival, reduces cortical GM2 and GM3 ganglioside accumulation and doubles the lifespan of NP-C mice [29].
  • Substitution of BUdR for thymidine does not significantly affect cell viability but does block cell differentiation in many different lineages [30].
  • Cell survival was increased by the activation of voltage-sensitive calcium channels (VSCCs) but not by activation of N-methyl-D-aspartate receptors [31].

Gene context of Cell Survival

  • TRAF proteins are major mediators for the cell activation, cell survival, and antiapoptotic functions of the TNF receptor superfamily [32].
  • This interaction is critical for cell viability; loss of Mdm2 causes cell death in vitro and in vivo in a p53-dependent manner [33].
  • Our results show that Jnk1 signals cell survival in transformed B lymphoblasts and suggest that it may contribute to the pathogenesis of some proliferative diseases [34].
  • The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID [35].
  • Derepression of the Crt1 regulon suppresses the lethality of mec1 and rad53 null alleles and is essential for cell viability during replicative stress [36].

Analytical, diagnostic and therapeutic context of Cell Survival


  1. Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. McGill, G.G., Horstmann, M., Widlund, H.R., Du, J., Motyckova, G., Nishimura, E.K., Lin, Y.L., Ramaswamy, S., Avery, W., Ding, H.F., Jordan, S.A., Jackson, I.J., Korsmeyer, S.J., Golub, T.R., Fisher, D.E. Cell (2002) [Pubmed]
  2. Homologous plant and bacterial proteins chaperone oligomeric protein assembly. Hemmingsen, S.M., Woolford, C., van der Vies, S.M., Tilly, K., Dennis, D.T., Georgopoulos, C.P., Hendrix, R.W., Ellis, R.J. Nature (1988) [Pubmed]
  3. Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions. Ling, K., Doughman, R.L., Firestone, A.J., Bunce, M.W., Anderson, R.A. Nature (2002) [Pubmed]
  4. p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas. Singh, B., Reddy, P.G., Goberdhan, A., Walsh, C., Dao, S., Ngai, I., Chou, T.C., O-Charoenrat, P., Levine, A.J., Rao, P.H., Stoffel, A. Genes Dev. (2002) [Pubmed]
  5. Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases. Muraoka, R.S., Dumont, N., Ritter, C.A., Dugger, T.C., Brantley, D.M., Chen, J., Easterly, E., Roebuck, L.R., Ryan, S., Gotwals, P.J., Koteliansky, V., Arteaga, C.L. J. Clin. Invest. (2002) [Pubmed]
  6. PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations. Baki, L., Shioi, J., Wen, P., Shao, Z., Schwarzman, A., Gama-Sosa, M., Neve, R., Robakis, N.K. EMBO J. (2004) [Pubmed]
  7. Dystrophin mutations predict cellular susceptibility to oxidative stress. Disatnik, M.H., Chamberlain, J.S., Rando, T.A. Muscle Nerve (2000) [Pubmed]
  8. Regulation of lymphocyte survival by the bcl-2 gene family. Cory, S. Annu. Rev. Immunol. (1995) [Pubmed]
  9. The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. Chang, L., Kamata, H., Solinas, G., Luo, J.L., Maeda, S., Venuprasad, K., Liu, Y.C., Karin, M. Cell (2006) [Pubmed]
  10. The enigmatic role of Sir2 in aging. Kennedy, B.K., Smith, E.D., Kaeberlein, M. Cell (2005) [Pubmed]
  11. IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Hu, M.C., Lee, D.F., Xia, W., Golfman, L.S., Ou-Yang, F., Yang, J.Y., Zou, Y., Bao, S., Hanada, N., Saso, H., Kobayashi, R., Hung, M.C. Cell (2004) [Pubmed]
  12. A mitochondrial protein, Bit1, mediates apoptosis regulated by integrins and Groucho/TLE corepressors. Jan, Y., Matter, M., Pai, J.T., Chen, Y.L., Pilch, J., Komatsu, M., Ong, E., Fukuda, M., Ruoslahti, E. Cell (2004) [Pubmed]
  13. Expression of the leukotriene D4 receptor CysLT1, COX-2, and other cell survival factors in colorectal adenocarcinomas. Ohd, J.F., Nielsen, C.K., Campbell, J., Landberg, G., Löfberg, H., Sjölander, A. Gastroenterology (2003) [Pubmed]
  14. Inhibition of nonlysosomal calcium-dependent proteolysis by glycine during anoxic injury of rat hepatocytes. Nichols, J.C., Bronk, S.F., Mellgren, R.L., Gores, G.J. Gastroenterology (1994) [Pubmed]
  15. Integrin alphav-mediated inactivation of p53 controls a MEK1-dependent melanoma cell survival pathway in three-dimensional collagen. Bao, W., Strömblad, S. J. Cell Biol. (2004) [Pubmed]
  16. ALADINI482S causes selective failure of nuclear protein import and hypersensitivity to oxidative stress in triple A syndrome. Hirano, M., Furiya, Y., Asai, H., Yasui, A., Ueno, S. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  17. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Pattingre, S., Tassa, A., Qu, X., Garuti, R., Liang, X.H., Mizushima, N., Packer, M., Schneider, M.D., Levine, B. Cell (2005) [Pubmed]
  18. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Datta, S.R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., Greenberg, M.E. Cell (1997) [Pubmed]
  19. The NUP1 gene encodes an essential component of the yeast nuclear pore complex. Davis, L.I., Fink, G.R. Cell (1990) [Pubmed]
  20. RPC40, a unique gene for a subunit shared between yeast RNA polymerases A and C. Mann, C., Buhler, J.M., Treich, I., Sentenac, A. Cell (1987) [Pubmed]
  21. Transcriptional activation of CLN1, CLN2, and a putative new G1 cyclin (HCS26) by SWI4, a positive regulator of G1-specific transcription. Ogas, J., Andrews, B.J., Herskowitz, I. Cell (1991) [Pubmed]
  22. Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress. Hirota, H., Chen, J., Betz, U.A., Rajewsky, K., Gu, Y., Ross, J., Müller, W., Chien, K.R. Cell (1999) [Pubmed]
  23. Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate. Lee, M.J., Thangada, S., Claffey, K.P., Ancellin, N., Liu, C.H., Kluk, M., Volpi, M., Sha'afi, R.I., Hla, T. Cell (1999) [Pubmed]
  24. Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival. Schipani, E., Ryan, H.E., Didrickson, S., Kobayashi, T., Knight, M., Johnson, R.S. Genes Dev. (2001) [Pubmed]
  25. Caspase activation by granzyme B is indirect, and caspase autoprocessing requires the release of proapoptotic mitochondrial factors. Sutton, V.R., Wowk, M.E., Cancilla, M., Trapani, J.A. Immunity (2003) [Pubmed]
  26. Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells. Stüber, E., Neurath, M., Calderhead, D., Fell, H.P., Strober, W. Immunity (1995) [Pubmed]
  27. Microtubule stabilization by taxol inhibits initiation of DNA synthesis by thrombin and by epidermal growth factor. Crossin, K.L., Carney, D.H. Cell (1981) [Pubmed]
  28. Induction of the Escherichia coli lactose operon selectively increases repair of its transcribed DNA strand. Mellon, I., Hanawalt, P.C. Nature (1989) [Pubmed]
  29. Niemann-Pick type C disease involves disrupted neurosteroidogenesis and responds to allopregnanolone. Griffin, L.D., Gong, W., Verot, L., Mellon, S.H. Nat. Med. (2004) [Pubmed]
  30. 5-bromo-2'-deoxyuridine blocks myogenesis by extinguishing expression of MyoD1. Tapscott, S.J., Lassar, A.B., Davis, R.L., Weintraub, H. Science (1989) [Pubmed]
  31. Requirement for BDNF in activity-dependent survival of cortical neurons. Ghosh, A., Carnahan, J., Greenberg, M.E. Science (1994) [Pubmed]
  32. A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction. Park, Y.C., Ye, H., Hsia, C., Segal, D., Rich, R.L., Liou, H.C., Myszka, D.G., Wu, H. Cell (2000) [Pubmed]
  33. Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53. Parant, J., Chavez-Reyes, A., Little, N.A., Yan, W., Reinke, V., Jochemsen, A.G., Lozano, G. Nat. Genet. (2001) [Pubmed]
  34. Survival signaling mediated by c-Jun NH(2)-terminal kinase in transformed B lymphoblasts. Hess, P., Pihan, G., Sawyers, C.L., Flavell, R.A., Davis, R.J. Nat. Genet. (2002) [Pubmed]
  35. The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID. Wang, S.L., Hawkins, C.J., Yoo, S.J., Müller, H.A., Hay, B.A. Cell (1999) [Pubmed]
  36. The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor. Huang, M., Zhou, Z., Elledge, S.J. Cell (1998) [Pubmed]
  37. CD45 links the B cell receptor with cell survival and is required for the persistence of germinal centers. Huntington, N.D., Xu, Y., Puthalakath, H., Light, A., Willis, S.N., Strasser, A., Tarlinton, D.M. Nat. Immunol. (2006) [Pubmed]
  38. Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines. Monks, A., Scudiero, D., Skehan, P., Shoemaker, R., Paull, K., Vistica, D., Hose, C., Langley, J., Cronise, P., Vaigro-Wolff, A. J. Natl. Cancer Inst. (1991) [Pubmed]
  39. Human clusterin gene expression is confined to surviving cells during in vitro programmed cell death. French, L.E., Wohlwend, A., Sappino, A.P., Tschopp, J., Schifferli, J.A. J. Clin. Invest. (1994) [Pubmed]
  40. Kupffer cells participate in early clearance of syngeneic hepatocytes transplanted in the rat liver. Joseph, B., Malhi, H., Bhargava, K.K., Palestro, C.J., McCuskey, R.S., Gupta, S. Gastroenterology (2002) [Pubmed]
  41. Yeast NOP2 encodes an essential nucleolar protein with homology to a human proliferation marker. de Beus, E., Brockenbrough, J.S., Hong, B., Aris, J.P. J. Cell Biol. (1994) [Pubmed]
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