Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

LOC344967 - acyl-CoA thioesterase 7 pseudogene

Homo sapiens

Jiang, R.C. et al.

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High impact information on LOC344967

Furthermore, the expression of LOC344967 was significantly up-regulated at both mRNA and protein levels in nasopharyngeal carcinoma cells sharing the -32G/A genotype compared with nasopharyngeal carcinoma cells with the -32G/G genotype [1].
Moreover, this -32A variant creates an activator protein (AP-1)-binding site in the transcriptional regulatory region of LOC344967, which significantly enhanced the binding of AP-1 to the promoter region and the transcription activity of the promoter in vivo [1].
Importantly, we found a novel gene (LOC344967) with a single nucleotide polymorphism -32G/A in the promoter region [1].
A functional variant in the transcriptional regulatory region of gene LOC344967 cosegregates with disease phenotype in familial nasopharyngeal carcinoma [1].

References

A functional variant in the transcriptional regulatory region of gene LOC344967 cosegregates with disease phenotype in familial nasopharyngeal carcinoma. Jiang, R.C., Qin, H.D., Zeng, M.S., Huang, W., Feng, B.J., Zhang, F., Chen, H.K., Jia, W.H., Chen, L.Z., Feng, Q.S., Zhang, R.H., Yu, X.J., Zheng, M.Z., Zeng, Y.X. Cancer Res. (2006) [Pubmed]

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