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Gene Review

NME9  -  NME/NM23 family member 9

Homo sapiens

Synonyms: NM23-H9, TXL-2, TXL2, TXNDC6, Thioredoxin domain-containing protein 6, ...
 
 
 
 
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High impact information on TXNDC6

  • Using in vitro translated proteins, we demonstrate that full-length Txl-2 weakly associates with microtubules [1].
  • By quantitative real time PCR we demonstrate that Txl-2 mRNA is ubiquitously expressed, with testis and lung having the highest levels of expression [1].
  • The Txl-2 gene spans approximately 28 kb, is organized into 11 exons, and maps at locus 3q22.3-q23 [1].
  • The Txl-2 open reading frame codes for a protein of 330 amino acids consisting of two distinct domains: an N-terminal domain typical of thioredoxins and a C-terminal domain belonging to the nucleoside-diphosphate kinase family, separated by a small interface domain [1].

References

  1. Characterization of human thioredoxin-like 2. A novel microtubule-binding thioredoxin expressed predominantly in the cilia of lung airway epithelium and spermatid manchette and axoneme. Sadek, C.M., Jiménez, A., Damdimopoulos, A.E., Kieselbach, T., Nord, M., Gustafsson, J.A., Spyrou, G., Davis, E.C., Oko, R., van der Hoorn, F.A., Miranda-Vizuete, A. J. Biol. Chem. (2003) [Pubmed]
 
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