The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • SNPedia

Table of contents

About

Terms

 

Gene Review: 

GABA-B-R1  -  metabotropic GABA-B receptor subtype 1

Drosophila melanogaster

Synonyms: BG:DS00929.6, CG15274, D-GABA[[B]]R1, D-Gaba1, Dmel\CG15274, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on GABA-B-R1

  • GABA(B) receptors are heterodimers of two subunits, GABA(B1) (GB1) and GABA(B2) (GB2) [1].
  • Here, we have further refined the GABA-binding site of GB1 and characterized the putative-binding site in the VFTM of GB2 [2].
  • Finally, although in either GB1 or the related metabotropic glutamate receptors most residues of the binding pocket are conserved from Caenorhabditis elegans to human, no such conservation is observed in GB2 [2].
 

Associations of GABA-B-R1 with chemical compounds

  • None of the residues important for GABA binding in GB1 appeared to be conserved in GB2 [2].

References

  1. Point Mutations in the Transmembrane Region of GABAB2 Facilitate Activation by the Positive Modulator N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) in the Absence of the GABAB1 Subunit. Dupuis, D.S., Relkovic, D., Lhuillier, L., Mosbacher, J., Kaupmann, K. Mol. Pharmacol. (2006) [Pubmed]
  2. No ligand binding in the GB2 subunit of the GABA(B) receptor is required for activation and allosteric interaction between the subunits. Kniazeff, J., Galvez, T., Labesse, G., Pin, J.P. J. Neurosci. (2002) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities