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Gene Review

GABA-B-R1  -  metabotropic GABA-B receptor subtype 1

Drosophila melanogaster

Synonyms: BG:DS00929.6, CG15274, D-GABA[[B]]R1, D-Gaba1, Dmel\CG15274, ...
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High impact information on GABA-B-R1

  • GABA(B) receptors are heterodimers of two subunits, GABA(B1) (GB1) and GABA(B2) (GB2) [1].
  • Here, we have further refined the GABA-binding site of GB1 and characterized the putative-binding site in the VFTM of GB2 [2].
  • Finally, although in either GB1 or the related metabotropic glutamate receptors most residues of the binding pocket are conserved from Caenorhabditis elegans to human, no such conservation is observed in GB2 [2].

Associations of GABA-B-R1 with chemical compounds

  • None of the residues important for GABA binding in GB1 appeared to be conserved in GB2 [2].


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