High impact information on BicC

• Embryos which develop from eggs produced in females with only one wild type copy of Bic-C show defects in anterior patterning and an abnormal persistence of oskar RNA in anterior regions [1].
• Bic-C RNA is localized to the oocyte in early oogenesis, and later concentrates at its anterior cortex [1].
• Bicaudal-C (Bic-C) is required during Drosophila melanogaster oogenesis for several processes, including anterior-posterior patterning [2].
• BIC-C protein expressed in mammalian cells can bind RNA in vitro, and a point mutation in one of the KH domains that causes a strong Bic-C phenotype weakens this binding [2].
• Dominant mutations at two loci, BicaudalC (BicC) and BicaudalD (BicD), cause heterozygous females to produce double-abdomen embryos [3].

Physical interactions of BicC

• Premature translation of oskar in oocytes lacking the RNA-binding protein bicaudal-C [2].

Analytical, diagnostic and therapeutic context of BicC

• 2. Expression analysis in mouse using in situ hybridization detects expression of Bicaudal-C not only in domains detected in Xenopus, but also in previously unreported regions [4].

References