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Gene Review

NMNAT3  -  nicotinamide nucleotide adenylyltransferase 3

Homo sapiens

Synonyms: FKSG76, NMN adenylyltransferase 3, NaMN adenylyltransferase 3, Nicotinamide mononucleotide adenylyltransferase 3, Nicotinate-nucleotide adenylyltransferase 3, ...
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High impact information on NMNAT3

  • The characterization of the cytosolic human PNAT-3 provided compelling evidence that the final steps of NAD biosynthesis pathways may exist in mammalian cytoplasm and mitochondria, potentially contributing to their NAD/NADP pool [1].
  • Both dinucleotides resulted selective inhibitors against human NMNAT-3 isoenzyme [2].


  1. Structural characterization of a human cytosolic NMN/NaMN adenylyltransferase and implication in human NAD biosynthesis. Zhang, X., Kurnasov, O.V., Karthikeyan, S., Grishin, N.V., Osterman, A.L., Zhang, H. J. Biol. Chem. (2003) [Pubmed]
  2. Synthesis and biological evaluation of NAD analogs as human pyridine nucleotide adenylyltransferase inhibitors. Franchetti, P., Petrelli, R., Cappellacci, L., Pasqualini, M., Vita, P., Sorci, L., Mazzola, F., Raffaelli, N., Magni, G. Nucleosides Nucleotides Nucleic Acids (2005) [Pubmed]
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