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Chemical Compound Review

AC1LA61U     [3-[[5-(2-amino-6-oxo-3H- purin-9-yl)-3...

Synonyms: 5'-AG-3'
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Disease relevance of AIDS-097589

  • Clusters of CpG dinucleotides implicated by nuclease hypersensitivity as control elements of housekeeping genes [1].
  • These findings, besides increasing the proportion of caucasian individuals whose haemophilia B carrier state can be diagnosed from 79% to 89%, demonstrate this widely applicable use of PCR for the detection of DNA polymorphism at cytosine phosphoguanadine dinucleotides irrespective of the methylation status [2].
  • These similarities, the presence of inverted repeats often ending with the dinucleotides U-G and C-A, and flanking imperfect direct repeats suggest that viroids may have originated from transposable elements or retroviral proviruses by deletion of interior portions of the viral (or element) DNA [3].
  • Despite comparable levels of unmethylated CpG dinucleotides, DNA from serotype 12 adenovirus is immune-stimulatory, but serotype 2 is nonstimulatory and can even inhibit activation by bacterial DNA [4].
  • Constitutively methylated CpG dinucleotides as mutation hot spots in the retinoblastoma gene (RB1) [5].

Psychiatry related information on AIDS-097589

  • Mutations of the methylated DNA binding protein MeCP2, a multifunctional protein that is thought to transmit epigenetic information encoded as methylated CpG dinucleotides to the transcriptional machinery, give rise to the debilitating neurodevelopmental disease Rett syndrome (RTT) [6].

High impact information on AIDS-097589


Chemical compound and disease context of AIDS-097589


Biological context of AIDS-097589


Anatomical context of AIDS-097589


Associations of AIDS-097589 with other chemical compounds


Gene context of AIDS-097589


Analytical, diagnostic and therapeutic context of AIDS-097589


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