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Gene Review

spvD  -  plasmid virulence protein

Salmonella enterica

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High impact information on spvD

  • The analysis supports the proposal that the chromosomal spv sequence more closely corresponds to the ancestral locus acquired during evolution of S. enterica, with plasmid acquisition of spv genes in the subspecies I strains involving addition of spvD and polymorphisms in spvA [1].
  • Inserts in spvC and spvD were unstable in vivo for unknown reasons, but these mutants still killed mice at slightly higher inocula [2].
  • Nucleotide sequence comparison revealed the existence of at least nine spvD alleles resulting in 8 SpvD protein variants although the nucleotide sequences were highly similar (identity 98.8-100%) [3].


  1. Characterization of the spv locus in Salmonella enterica serovar Arizona. Libby, S.J., Lesnick, M., Hasegawa, P., Kurth, M., Belcher, C., Fierer, J., Guiney, D.G. Infect. Immun. (2002) [Pubmed]
  2. Characterization of translation termination mutations in the spv operon of the Salmonella virulence plasmid pSDL2. Roudier, C., Fierer, J., Guiney, D.G. J. Bacteriol. (1992) [Pubmed]
  3. Sequence polymorphism of the Salmonella plasmid virulence factor D (SpvD) in Salmonella enterica isolates of animal origin. Bauerfeind, R., Barth, S., Weiss, R., Baljer, G. Berl. Munch. Tierarztl. Wochenschr. (2001) [Pubmed]
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