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Gene Review

spvC  -  plasmid virulence protein

Salmonella enterica

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Disease relevance of spvC

  • Of the 22 Salmonella isolates examined, 15 were positive for the invasion gene invA and the virulence plasmid-associated genes spvC and pef [1].
 

High impact information on spvC

  • DNA from chloramphenicol-resistant clones was sequenced, and probes specific for the genes floS. typhimurium (floSt), int, invA, and spvC were produced for colony blot hybridizations [2].
  • In contrast, when 23 commonly seen Salmonella serovars (38 isolates) were tested, all were shown to carry the invA gene and seven concomitantly harbored the spvC gene of the virulence plasmid [3].
  • Rapid identification of Salmonella serovars in feces by specific detection of virulence genes, invA and spvC, by an enrichment broth culture-multiplex PCR combination assay [3].
  • Inserts in spvC and spvD were unstable in vivo for unknown reasons, but these mutants still killed mice at slightly higher inocula [4].
 

Biological context of spvC

  • The serovar-specific large plasmid was detected by PCR for spvC in 100% of DT104 strains and in 77% of the non-DT104 strains [5].

References

  1. Genetic relatedness of Salmonella isolates from nondomestic birds in Southeastern United States. Hudson, C.R., Quist, C., Lee, M.D., Keyes, K., Dodson, S.V., Morales, C., Sanchez, S., White, D.G., Maurer, J.J. J. Clin. Microbiol. (2000) [Pubmed]
  2. Detection of multidrug-resistant Salmonella enterica serotype typhimurium DT104 based on a gene which confers cross-resistance to florfenicol and chloramphenicol. Bolton, L.F., Kelley, L.C., Lee, M.D., Fedorka-Cray, P.J., Maurer, J.J. J. Clin. Microbiol. (1999) [Pubmed]
  3. Rapid identification of Salmonella serovars in feces by specific detection of virulence genes, invA and spvC, by an enrichment broth culture-multiplex PCR combination assay. Chiu, C.H., Ou, J.T. J. Clin. Microbiol. (1996) [Pubmed]
  4. Characterization of translation termination mutations in the spv operon of the Salmonella virulence plasmid pSDL2. Roudier, C., Fierer, J., Guiney, D.G. J. Bacteriol. (1992) [Pubmed]
  5. Epidemiology and characterization of animal Salmonella enterica subspecies Enterica serotype typhimurium DT104 in Hungary. Szmollény, G., Kostyák, A., Kovács, S., Speed, K., Jones, Y., László, V.G., Gadó, I., Pászti, J., Wray, C., Nagy, B. Acta Vet. Hung. (2000) [Pubmed]
 
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