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Gene Review:

Tc00.1047053511353.69 - oxidoreductase-protein

Trypanosoma cruzi strain CL Brener

Tovar, J. et al., Tsuhako, M.H. et al.

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High impact information on Tc00.1047053511353.69

Direct ESR detection and characterization by computer simulation of the megazol nitro anion radical were possible in the presence of NADPH and ferredoxin: NADP+ oxidoreductase under anaerobic conditions [1].

Analytical, diagnostic and therapeutic context of Tc00.1047053511353.69

Trypanothione reductase (TR), a flavoprotein oxidoreductase present in trypanosomatids but absent in human cells, is regarded as a potential target for the chemotherapy of several tropical parasitic diseases caused by trypanosomes and leishmanias [2].

References

Restricted bioreductive metabolism of a nitroimidazole-thiadiazole derivative with curative action in experimental Trypanosoma cruzi infections. Tsuhako, M.H., Alves, M.J., Colli, W., Brener, Z., Augusto, O. Biochem. Pharmacol. (1989) [Pubmed]
Extrachromosomal, homologous expression of trypanothione reductase and its complementary mRNA in Trypanosoma cruzi. Tovar, J., Fairlamb, A.H. Nucleic Acids Res. (1996) [Pubmed]

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