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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

128up  -  upstream of RpIII128

Drosophila melanogaster

Synonyms: CG8340, Dmel\CG8340, GTP-binding protein 128up, GTP-bp, X71866
 
 
 
 
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High impact information on 128up

  • The intergenic distance between the 3' end of 128up mRNA and the 5' end of DmRP128 mRNA is only about 100 bp [1].
  • Bacterially expressed 128up protein fused to maltose-binding protein specifically binds GTP [1].
  • In accordance with the sequence conservation, antibodies against 128up specifically cross-react with mouse 3T3 cells and human Hep2 cells where the subcellular localization of the protein is predominantly perinuclear [1].
 

Analytical, diagnostic and therapeutic context of 128up

  • Sequence analysis of 128up cDNA reveals that the gene codes for a 41 kDa protein with homology to GTP-binding proteins and matching four of the structural sequence motifs characteristic of the superfamily of GTPases [1].

References

  1. The gene upstream of DmRP128 codes for a novel GTP-binding protein of Drosophila melanogaster. Sommer, K.A., Petersen, G., Bautz, E.K. Mol. Gen. Genet. (1994) [Pubmed]
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