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Gene Review: 

flmA  -  small toxic polypeptide

Escherichia coli O157:H7 str. EDL933

 
 
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Disease relevance of flmA

  • The Escherichia coli Xer site-specific recombination system acts at sites such as ColE1 cer to resolve plasmid multimers formed by homologous recombination, thereby maintaining plasmids in a monomeric state and helping to ensure stable plasmid inheritance [1].
 

High impact information on flmA

  • S1 analysis and functional studies suggest that the antisense flmB RNA binds to the flmA RNA and suppresses the expression of the lethal product, presumably by blocking coupled translation of ORF70 and flmA [2].
  • We suggest that when these RNA species are retained by cells which have lost the F plasmid, the more stable flmA RNA will eventually be translated thus leading to cell death [2].
  • The flmA RNA also encodes an open reading frame (ORF70) which overlaps the flmA-coding sequence and may be a third gene involved in the Flm function [2].
 

Other interactions of flmA

  • Secondary structure analysis predicts that the flmA RNA is extremely stable compared to the regulatory flmB RNA [2].

References

  1. Stability by multimer resolution of pJHCMW1 is due to the Tn1331 resolvase and not to the Escherichia coli Xer system. Tolmasky, M.E., Colloms, S., Blakely, G., Sherratt, D.J. Microbiology (Reading, Engl.) (2000) [Pubmed]
  2. Nucleotide sequence and transcriptional analysis of a third function (Flm) involved in F-plasmid maintenance. Loh, S.M., Cram, D.S., Skurray, R.A. Gene (1988) [Pubmed]
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