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Gene Review: 

Sema-1b  -  CG6446 gene product from transcript CG6446-RA

Drosophila melanogaster

Synonyms: BcDNA:GH03186, CG6446, D-semaIII, Dmel\CG6446, Sema 1b, ...
 
 
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High impact information on Sema-1b

  • Here we show that in the mutants, some sensory axons project into inappropriate regions of the spinal cord where semaIII is normally expressed [1].
  • In this issue of Neuron, two beautiful studies in Drosophila by Lattemann et al. and Sweeney et al. show that Semaphorin repulsion regulates interactions between olfactory receptor neurons to help axons find their correct targets [2].

References

  1. Semaphorin III is needed for normal patterning and growth of nerves, bones and heart. Behar, O., Golden, J.A., Mashimo, H., Schoen, F.J., Fishman, M.C. Nature (1996) [Pubmed]
  2. Semaphorin directs axon traffic in the fly olfactory system. Bashaw, G.J. Neuron (2007) [Pubmed]
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