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Gene Review:

bchI - protoporphyrin IX magnesium-chelatase

Rhodobacter sphaeroides 2.4.1

Papenbrock, J. et al., Gibson, L.C. et al., Gibson, L.C. et al.

Gibson, Jensen, Hunter,

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Disease relevance of bchI

The bchH and the bchI and -D genes from R. sphaeroides were expressed in Escherichia coli [1].
In Rhodobacter sphaeroides, and Synechocystis, the three open reading frames bchD/chID, bchH/chIH and bchI/chII encode proteins which are required for in vitro Mg-chelatase activity [2].
In the photosynthetic bacterium Rhodobacter sphaeroides, this reaction is catalysed by the products of the bchI, bchD and bchH genes [3].

References

Magnesium-protoporphyrin chelatase of Rhodobacter sphaeroides: reconstitution of activity by combining the products of the bchH, -I, and -D genes expressed in Escherichia coli. Gibson, L.C., Willows, R.D., Kannangara, C.G., von Wettstein, D., Hunter, C.N. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
Mg-chelatase of tobacco: identification of a Chl D cDNA sequence encoding a third subunit, analysis of the interaction of the three subunits with the yeast two-hybrid system, and reconstitution of the enzyme activity by co-expression of recombinant CHL D, CHL H and CHL I. Papenbrock, J., Gräfe, S., Kruse, E., Hänel, F., Grimm, B. Plant J. (1997) [Pubmed]
Magnesium chelatase from Rhodobacter sphaeroides: initial characterization of the enzyme using purified subunits and evidence for a BchI-BchD complex. Gibson, L.C., Jensen, P.E., Hunter, C.N. Biochem. J. (1999) [Pubmed]

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