Gene Review:
cer - crammer
Drosophila melanogaster
Synonyms:
CER, CG10460, D/CTLA-2, Dmel\CG10460
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Psychiatry related information on cer
- The cer gene encodes an inhibitor of a subfamily of cysteine proteinases, named cathepsins, some of which might be involved in human Alzheimer's disease [1].
High impact information on cer
- The overexpression of cer in glial cells but not in MB neurons induces a decrease in LTM, suggesting that Cer might have a role in glia and that the concentration of the Cer peptide is critical for LTM [1].
Associations of cer with chemical compounds
- In wild-type flies, cer expression transiently decreases after LTM conditioning, indicating that cysteine proteinases are activated early in LTM formation [1].
References
- Drosophila long-term memory formation involves regulation of cathepsin activity. Comas, D., Petit, F., Preat, T. Nature (2004) [Pubmed]
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