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Gene Review:

SpZ12-1 - DNA-binding protein with twelve Zn fingers

Strongylocentrotus purpuratus

Wang, D.G. et al., Harrington, M.G. et al.

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High impact information on SpZ12-1

SpZ12-1, a negative regulator required for spatial control of the territory-specific CyIIIa gene in the sea urchin embryo [1].
SpZ12-1 is the only DNA-binding protein in embryo nuclear extract that interacts with the specific cis-target sites required for repression of CyIIIa.CAT in skeletogenic mesenchyme and is likely to be the trans factor that mediates this repression [1].
Three factors, SpZ12-1, SpP3A2, and SpRunt-1, were studied at different stages of embryonic development [2].

References

SpZ12-1, a negative regulator required for spatial control of the territory-specific CyIIIa gene in the sea urchin embryo. Wang, D.G., Kirchhamer, C.V., Britten, R.J., Davidson, E.H. Development (1995) [Pubmed]
Covalent variation is a general property of transcription factors in the sea urchin embryo. Harrington, M.G., Coffman, J.A., Davidson, E.H. Mol. Marine Biol. Biotechnol. (1997) [Pubmed]

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