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Gene Review:

scg3 - secretogranin III

Xenopus laevis

Synonyms: SgIII, scg3-A

Holthuis, J.C. et al., Van Horssen, A.M. et al.

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High impact information on scg3-A

Dithiothreitol did not affect transport, sorting, and cleavage of secretogranin III, which lacks disulfide bonds [1].
Pulse-chase incubations in combination with immunoprecipitation analysis were used to monitor the fates of the prohormone proopiomelanocortin (POMC), prohormone convertase PC2 and its helper protein 7B2, as well as secretogranin III [1].
A comparative analysis of the Xenopus and mammalian proteins revealed a striking regional conservation with an overall sequence identity of 48% for SgII and 61% for SgIII [2].
Moreover, SgIII contains a conserved and repeated motif (DSTK) that is reminiscent of a repeat present in the trans-Golgi network integral membrane proteins TGN38 and TGN41, a finding more consistent with an intracellular function for this protein [2].

Other interactions of scg3-A

However, in SgII and especially in SgIII, a substantial portion of the potential dibasic cleavage sites is not conserved, arguing against the idea that these granins serve solely as peptide precursors [2].

References

Manipulation of disulfide bonds differentially affects the intracellular transport, sorting, and processing of neuroendocrine secretory proteins. Van Horssen, A.M., Van Kuppeveld, F.J., Martens, G.J. J. Neurochem. (1998) [Pubmed]
The neuroendocrine proteins secretogranin II and III are regionally conserved and coordinately expressed with proopiomelanocortin in Xenopus intermediate pituitary. Holthuis, J.C., Martens, G.J. J. Neurochem. (1996) [Pubmed]

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