Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

PTP-ER - Protein tyrosine phosphatase-ERK/Enhancer...

Drosophila melanogaster

Synonyms: CG9856, Dmel\CG9856, ER2-5, ptp-er

Karim, F.D. et al., Rintelen, F. et al.

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High impact information on PTP-ER

Ectopic expression of PTP-ER dramatically inhibits RAS1/MAPK signaling [1].
Resistance to PTP-ER activity partially accounts for the Sevenmaker mutant phenotype [1].
We have cloned and characterized a novel cytoplasmic protein tyrosine phosphatase, PTP-ER, which is related to mammalian PCPTP1, LC-PTP/HePTP, and STEP tyrosine phosphatases [1].
By genetic analysis we show that DMKP3 and the tyrosine phosphatase PTP-ER perform partially redundant functions on the same substrate, ERK [2].

Associations of PTP-ER with chemical compounds

The Drosophila dual-specificity ERK phosphatase DMKP3 cooperates with the ERK tyrosine phosphatase PTP-ER [2].

Other interactions of PTP-ER

PTP-ER mutants produce extra R7 cells and enhance activated Ras1 signaling [1].

References

PTP-ER, a novel tyrosine phosphatase, functions downstream of Ras1 to downregulate MAP kinase during Drosophila eye development. Karim, F.D., Rubin, G.M. Mol. Cell (1999) [Pubmed]
The Drosophila dual-specificity ERK phosphatase DMKP3 cooperates with the ERK tyrosine phosphatase PTP-ER. Rintelen, F., Hafen, E., Nairz, K. Development (2003) [Pubmed]

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