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Gene Review:

snRNA:U1:95Ca - small nuclear RNA U1 at 95Ca

Drosophila melanogaster

Synonyms: 95C U1, CR31341, DMU1951, Dmel\CR31341, K5, ...

Herrera, R.J. et al., Wieben, E.D. et al.

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High impact information on snRNA:U1:95Ca

Thus, even though the nucleotide sequences of Drosophila and human U1 RNA are about 72% homologous, and the corresponding RNPs are both recognized by the same human autoantibody, Drosophila U1 RNP appears to have a simpler protein complement than its mammalian counterpart [1].
The two Drosophila U1 RNA-associated proteins are synthesized at normal or slightly increased rates during the heat shock response and are incorporated into antibody-recognizable RNP complexes [1].
The two pseudogenes possess highly conserved sequences with the B.mori U1 gene only for the first 101 nucleotides [2].
The Bm1 family consensus sequence exhibits 53% sequence similarity with the composite U1 gene [2].

Biological context of snRNA:U1:95Ca

These findings are indicative of at least two different categories of U1-related sequences in B.mori, one with a possible evolutionary relationship to the Bm1 family of repetitive elements and the other representing characteristic processed pseudogenes with retroposon mode of dispersion and target selection for the TTTA hotspot [2].

References

Small nuclear ribonucleoproteins of Drosophila: identification of U1 RNA-associated proteins and their behavior during heat shock. Wieben, E.D., Pederson, T. Mol. Cell. Biol. (1982) [Pubmed]
Evidence for a relationship between the Bombyx mori middle repetitive Bm1 sequence family and U1 snRNA. Herrera, R.J., Wang, J. Genetica (1991) [Pubmed]

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