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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Heat-Shock Response

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Disease relevance of Heat-Shock Response


Psychiatry related information on Heat-Shock Response


High impact information on Heat-Shock Response


Chemical compound and disease context of Heat-Shock Response


Biological context of Heat-Shock Response


Anatomical context of Heat-Shock Response


Associations of Heat-Shock Response with chemical compounds


Gene context of Heat-Shock Response

  • Expression of genes under the control of known heat shock-inducible promoter elements (HSEs and STREs) was not compromised in PKC1 pathway mutants, indicating that this pathway mediates a novel aspect of the yeast heat shock response [30].
  • In contrast, nonsteroidal antiinflammatory drugs triggered only an incomplete heat shock response, with HSF1 activation but not hsp70 induction, whereas steroids and immunosuppressive drugs did not affect the heat shock response at all [31].
  • Overexpression of DROJ1 in Drosophila SL2 cells delays the onset of the heat shock response [32].
  • Hsp78 appears to act in concert with other mitochondrial chaperone proteins since a conditioning pretreatment of the cells to induce the cellular heat shock response is required to maintain mitochondrial functions under severe temperature stress [33].
  • We show that the Gcn5/Ada complex is selectively required for the unfolded protein response but not for the heat shock response [34].

Analytical, diagnostic and therapeutic context of Heat-Shock Response


  1. The dnaK protein modulates the heat-shock response of Escherichia coli. Tilly, K., McKittrick, N., Zylicz, M., Georgopoulos, C. Cell (1983) [Pubmed]
  2. Membrane physical state controls the signaling mechanism of the heat shock response in Synechocystis PCC 6803: identification of hsp17 as a "fluidity gene". Horváth, I., Glatz, A., Varvasovszki, V., Török, Z., Páli, T., Balogh, G., Kovács, E., Nádasdi, L., Benkö, S., Joó, F., Vígh, L. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  3. The heat shock response in HeLa cells is accompanied by elevated expression of the c-fos proto-oncogene. Andrews, G.K., Harding, M.A., Calvet, J.P., Adamson, E.D. Mol. Cell. Biol. (1987) [Pubmed]
  4. Deleterious and protective properties of an aggregate-prone protein with a polyalanine expansion. Berger, Z., Davies, J.E., Luo, S., Pasco, M.Y., Majoul, I., O'Kane, C.J., Rubinsztein, D.C. Hum. Mol. Genet. (2006) [Pubmed]
  5. Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease. Sittler, A., Lurz, R., Lueder, G., Priller, J., Lehrach, H., Hayer-Hartl, M.K., Hartl, F.U., Wanker, E.E. Hum. Mol. Genet. (2001) [Pubmed]
  6. Amyloid precursor protein heat shock response in lymphoblastoid cell lines bearing presenilin-1 mutations. Johnston, J.A., Lannfelt, L., Wiehager, B., O'Neill, C., Cowburn, R.F. Biochim. Biophys. Acta (1997) [Pubmed]
  7. Heat shock factor and the heat shock response. Sorger, P.K. Cell (1991) [Pubmed]
  8. Topoisomerase I interacts with transcribed regions in Drosophila cells. Gilmour, D.S., Pflugfelder, G., Wang, J.C., Lis, J.T. Cell (1986) [Pubmed]
  9. Effect of sodium salicylate on the human heat shock response. Jurivich, D.A., Sistonen, L., Kroes, R.A., Morimoto, R.I. Science (1992) [Pubmed]
  10. Molecular chaperones as HSF1-specific transcriptional repressors. Shi, Y., Mosser, D.D., Morimoto, R.I. Genes Dev. (1998) [Pubmed]
  11. Negative regulation of the heat shock transcriptional response by HSBP1. Satyal, S.H., Chen, D., Fox, S.G., Kramer, J.M., Morimoto, R.I. Genes Dev. (1998) [Pubmed]
  12. Heat shock proteins and antigens of Mycobacterium tuberculosis. Young, D.B., Garbe, T.R. Infect. Immun. (1991) [Pubmed]
  13. Proteolysis of heat shock transcription factor is associated with apoptosis in rat Nb2 lymphoma cells. Zhang, M., Blake, M.J., Gout, P.W., Buckley, D.J., Buckley, A.R. Cell Growth Differ. (1999) [Pubmed]
  14. Protein synthesis inhibitors and ethanol selectively enhance heterologous expression of P450s and related proteins in Escherichia coli. Kusano, K., Waterman, M.R., Sakaguchi, M., Omura, T., Kagawa, N. Arch. Biochem. Biophys. (1999) [Pubmed]
  15. Inhibition of the heat shock response and synthesis of glucose-regulated proteins in Ca2+-deprived rat hepatoma cells. Lamarche, S., Chrétien, P., Landry, J. Biochem. Biophys. Res. Commun. (1985) [Pubmed]
  16. Induction of the 72-kilodalton heat shock protein and protection from ultraviolet B-induced cell death in human keratinocytes by repetitive exposure to heat shock or 15-deoxy-delta(12,14)-prostaglandin J2. Merwald, H., Kokesch, C., Klosner, G., Matsui, M., Trautinger, F. Cell Stress Chaperones (2006) [Pubmed]
  17. Bag1-Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth. Song, J., Takeda, M., Morimoto, R.I. Nat. Cell Biol. (2001) [Pubmed]
  18. Purification of the heteromeric protein binding to the URS1 transcriptional repression site in Saccharomyces cerevisiae. Luche, R.M., Smart, W.C., Cooper, T.G. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  19. Proline isomerases function during heat shock. Sykes, K., Gething, M.J., Sambrook, J. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  20. Protein phosphatase 2A activity affects histone H3 phosphorylation and transcription in Drosophila melanogaster. Nowak, S.J., Pai, C.Y., Corces, V.G. Mol. Cell. Biol. (2003) [Pubmed]
  21. Attenuation of the heat shock response in HeLa cells is mediated by the release of bound heat shock transcription factor and is modulated by changes in growth and in heat shock temperatures. Abravaya, K., Phillips, B., Morimoto, R.I. Genes Dev. (1991) [Pubmed]
  22. Concurrent collapse of keratin filaments, aggregation of organelles, and inhibition of protein synthesis during the heat shock response in mammary epithelial cells. Shyy, T.T., Asch, B.B., Asch, H.L. J. Cell Biol. (1989) [Pubmed]
  23. Disruption of the HSF3 gene results in the severe reduction of heat shock gene expression and loss of thermotolerance. Tanabe, M., Kawazoe, Y., Takeda, S., Morimoto, R.I., Nagata, K., Nakai, A. EMBO J. (1998) [Pubmed]
  24. Osmotic regulation of the heat shock response in primary rat hepatocytes. Kurz, A.K., Schliess, F., Häussinger, D. Hepatology (1998) [Pubmed]
  25. Heat-shock protein synthesis by human polymorphonuclear cells. Eid, N.S., Kravath, R.E., Lanks, K.W. J. Exp. Med. (1987) [Pubmed]
  26. Heat shock protects cultured neurons from glutamate toxicity. Rordorf, G., Koroshetz, W.J., Bonventre, J.V. Neuron (1991) [Pubmed]
  27. 1,25-Dihydroxyvitamin D3 increases the toxicity of hydrogen peroxide in the human monocytic line U937: the role of calcium and heat shock. Polla, B.S., Bonventre, J.V., Krane, S.M. J. Cell Biol. (1988) [Pubmed]
  28. Identification and characterization of HsIV HsIU (ClpQ ClpY) proteins involved in overall proteolysis of misfolded proteins in Escherichia coli. Missiakas, D., Schwager, F., Betton, J.M., Georgopoulos, C., Raina, S. EMBO J. (1996) [Pubmed]
  29. AppppA, heat-shock stress, and cell oxidation. Lee, P.C., Bochner, B.R., Ames, B.N. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  30. The protein kinase C-activated MAP kinase pathway of Saccharomyces cerevisiae mediates a novel aspect of the heat shock response. Kamada, Y., Jung, U.S., Piotrowski, J., Levin, D.E. Genes Dev. (1995) [Pubmed]
  31. Enhanced expression of heat shock protein 70 (hsp70) and heat shock factor 1 (HSF1) activation in rheumatoid arthritis synovial tissue. Differential regulation of hsp70 expression and hsf1 activation in synovial fibroblasts by proinflammatory cytokines, shear stress, and antiinflammatory drugs. Schett, G., Redlich, K., Xu, Q., Bizan, P., Gröger, M., Tohidast-Akrad, M., Kiener, H., Smolen, J., Steiner, G. J. Clin. Invest. (1998) [Pubmed]
  32. Modulation of Drosophila heat shock transcription factor activity by the molecular chaperone DROJ1. Marchler, G., Wu, C. EMBO J. (2001) [Pubmed]
  33. The molecular chaperone Hsp78 confers compartment-specific thermotolerance to mitochondria. Schmitt, M., Neupert, W., Langer, T. J. Cell Biol. (1996) [Pubmed]
  34. Gene induction in response to unfolded protein in the endoplasmic reticulum is mediated through Ire1p kinase interaction with a transcriptional coactivator complex containing Ada5p. Welihinda, A.A., Tirasophon, W., Green, S.R., Kaufman, R.J. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  35. Tributyltin is a potent inducer of the heat shock response in human diploid fibroblasts. Zhang, H., Liu, A.Y. J. Cell. Physiol. (1992) [Pubmed]
  36. HSF3 is a major heat shock responsive factor duringchicken embryonic development. Kawazoe, Y., Tanabe, M., Sasai, N., Nagata, K., Nakai, A. Eur. J. Biochem. (1999) [Pubmed]
  37. Embryonic and maternal heat shock responses to a teratogenic hyperthermic insult. Bennett, G.D., Mohl, V.K., Finnell, R.H. Reprod. Toxicol. (1990) [Pubmed]
  38. Optimizing the promoter and ribosome binding sequence for expression of human single chain urokinase-like plasminogen activator in Escherichia coli and stabilization of the product by avoiding heat shock response. Surek, B., Wilhelm, M., Hillen, W. Appl. Microbiol. Biotechnol. (1991) [Pubmed]
  39. Ketamine reduces mortality of severely burnt rats, when compared to midazolam plus fentanyl. Neder Meyer, T., Lázaro Da Silva, A. Burns : journal of the International Society for Burn Injuries. (2004) [Pubmed]
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