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Gene Review:

bacA - transporter

Brucella melitensis biovar Abortus 2308

Parent, M.A. et al., Manterola, L. et al.

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Disease relevance of bacA

Transcription of Brucella genes required for incorporating long acyl chains into lipid A (acpXL and lpxXL) or implicated in lipid A acylation control (bacA) was not affected [1].

High impact information on bacA

We conclude that attenuation properties of bacA mutation are dependent upon the nature of the host but more importantly that bacterial gene deletion can result in increased host pathology without an increase in bacterial load, crucial considerations for vaccine design [2].

References

The lipopolysaccharide of Brucella abortus BvrS/BvrR mutants contains lipid A modifications and has higher affinity for bactericidal cationic peptides. Manterola, L., Moriyón, I., Moreno, E., Sola-Landa, A., Weiss, D.S., Koch, M.H., Howe, J., Brandenburg, K., López-Goñi, I. J. Bacteriol. (2005) [Pubmed]
Brucella abortus bacA mutant induces greater pro-inflammatory cytokines than the wild-type parent strain. Parent, M.A., Goenka, R., Murphy, E., Levier, K., Carreiro, N., Golding, B., Ferguson, G., Roop, R.M., Walker, G.C., Baldwin, C.L. Microbes Infect. (2007) [Pubmed]

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