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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

clpB  -  ATP-dependent protease protein

Staphylococcus aureus RF122

 
 
 
 
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High impact information on clpB

  • These defects were paralleled by an inability of the clpC mutant to grow at high temperature and of the clpB mutant to induce thermotolerance indicating that the protective functions of these proteins are required both at high temperature and during infection [1].
  • In the present study, we have inactivated clpC, clpB and clpL and, while none of these mutations affected toxin production, both ClpC and ClpB and to a minor extent ClpL were required for intracellular multiplication within bovine mammary epithelial cells [1].

References

  1. Clp ATPases are required for stress tolerance, intracellular replication and biofilm formation in Staphylococcus aureus. Frees, D., Chastanet, A., Qazi, S., Sørensen, K., Hill, P., Msadek, T., Ingmer, H. Mol. Microbiol. (2004) [Pubmed]
 
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