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Gene Review

Rsl1  -  regulator of sex limited protein 1

Mus musculus

Synonyms: rslcan-9
 
 
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High impact information on Rsl1

  • Among eight Rsl candidate (Rslcan) genes within the critical genetic interval, the recent duplicates Rslcan-4 and Rslcan-9 both harbor mutations in rsl mice (partial deletion and splice-site inactivation, respectively) [1].
  • Here we compare Rsl1 and Rsl2 with their neighboring genes, tracing a series of duplication, inversion, and gene conversion events that have created subfamilies within the locus [2].
 

Biological context of Rsl1

  • We recently identified mutations in two genes, Rsl1 and Rsl2, accounting for the rsl phenotype [2].

References

  1. Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression. Krebs, C.J., Larkins, L.K., Price, R., Tullis, K.M., Miller, R.D., Robins, D.M. Genes Dev. (2003) [Pubmed]
  2. Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2. Krebs, C.J., Larkins, L.K., Khan, S.M., Robins, D.M. Genomics (2005) [Pubmed]
 
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