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Gene Review

Vgf  -  VGF nerve growth factor inducible

Mus musculus

Synonyms: Gm1052, LOC381677
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High impact information on Vgf

  • To determine the function of VGF, a secreted polypeptide that is synthesized by neurons, is abundant in the hypothalamus, and is regulated in the brain by electrical activity, injury, and the circadian clock, we generated knockout mice lacking Vgf [1].


  1. Targeted deletion of the Vgf gene indicates that the encoded secretory peptide precursor plays a novel role in the regulation of energy balance. Hahm, S., Mizuno, T.M., Wu, T.J., Wisor, J.P., Priest, C.A., Kozak, C.A., Boozer, C.N., Peng, B., McEvoy, R.C., Good, P., Kelley, K.A., Takahashi, J.S., Pintar, J.E., Roberts, J.L., Mobbs, C.V., Salton, S.R. Neuron (1999) [Pubmed]
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