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Gene Review

Vgf  -  VGF nerve growth factor inducible

Rattus norvegicus

Synonyms: Neurosecretory protein VGF, VGF8a protein
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High impact information on Vgf

  • Antibodies directed against recombinant VGF8a-beta-galactosidase fusion proteins were used for immunofluorescent staining of the protein in PC12 cells as well as for its localization, by Western blot analysis, in subfractions of cell homogenates [1].
  • We demonstrate that in PC12 cells, VGF8a protein is stored in secretory vesicles and is released in response to a variety of stimuli that are known to induce the regulated secretion of neurotransmitters [1].
  • We report here the complete amino acid sequence of the protein (named VGF8a) as deduced by nucleotide sequencing of overlapping cDNA clones [1].
  • VGF8a is particularly rich in proline residues and has a conspicuous number of short stretches of basic amino acid residues which may represent potential targets for proteolytic cleavage [1].
  • The structural organization of the human gene is similar to that described for the rat Vgf gene (S. R. J. Salton et al., 1991, Mol. Cell. Biol. 11: 2335-2349) and both the translated and the untranslated regions show a high degree of sequence homology to the rat gene [2].


  1. A protein induced by NGF in PC12 cells is stored in secretory vesicles and released through the regulated pathway. Possenti, R., Eldridge, J.D., Paterson, B.M., Grasso, A., Levi, A. EMBO J. (1989) [Pubmed]
  2. Cloning, structural organization analysis, and chromosomal assignment of the human gene for the neurosecretory protein VGF. Canu, N., Possenti, R., Ricco, A.S., Rocchi, M., Levi, A. Genomics (1997) [Pubmed]
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