MeSH Review:
Mice, Knockout
Strehler,
Zacharias,
Wynn,
Calandra,
Echtenacher,
Roy,
Pugin,
Metz,
Hültner,
Heumann,
Männel,
Bucala,
Glauser,
Shih,
Chen,
Ridd,
Endres,
Biniszkiewicz,
Sobol,
Harms,
Ahmadi,
Lipski,
Katchanov,
Mergenthaler,
Dirnagl,
Wilson,
Meisel,
Jaenisch,
O'Donnell,
Warren,
Rossi,
Zlotnik,
Holzenberger,
Dupont,
Ducos,
Leneuve,
Géloën,
Even,
Cervera,
Le Bouc,
Ravetch,
Bolland,
- Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps. Strehler, E.E., Zacharias, D.A. Physiol. Rev. (2001)
- Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes. Takaku, K., Oshima, M., Miyoshi, H., Matsui, M., Seldin, M.F., Taketo, M.M. Cell (1998)
- Protection from septic shock by neutralization of macrophage migration inhibitory factor. Calandra, T., Echtenacher, B., Roy, D.L., Pugin, J., Metz, C.N., Hültner, L., Heumann, D., Männel, D., Bucala, R., Glauser, M.P. Nat. Med. (2000)
- A decade of molecular studies of fragile X syndrome. O'Donnell, W.T., Warren, S.T. Annu. Rev. Neurosci. (2002)
- Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice. Sonoshita, M., Takaku, K., Sasaki, N., Sugimoto, Y., Ushikubi, F., Narumiya, S., Oshima, M., Taketo, M.M. Nat. Med. (2001)
- Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Chemelli, R.M., Willie, J.T., Sinton, C.M., Elmquist, J.K., Scammell, T., Lee, C., Richardson, J.A., Williams, S.C., Xiong, Y., Kisanuki, Y., Fitch, T.E., Nakazato, M., Hammer, R.E., Saper, C.B., Yanagisawa, M. Cell (1999)
- Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine. Lindskog, M., Svenningsson, P., Pozzi, L., Kim, Y., Fienberg, A.A., Bibb, J.A., Fredholm, B.B., Nairn, A.C., Greengard, P., Fisone, G. Nature (2002)
- Neuroendocrine basis of social recognition. Winslow, J.T., Insel, T.R. Curr. Opin. Neurobiol. (2004)
- 'Tissue' transglutaminase ablation reduces neuronal death and prolongs survival in a mouse model of Huntington's disease. Mastroberardino, P.G., Iannicola, C., Nardacci, R., Bernassola, F., De Laurenzi, V., Melino, G., Moreno, S., Pavone, F., Oliverio, S., Fesus, L., Piacentini, M. Cell Death Differ. (2002)
- Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channels. Ma, T., Yang, B., Gillespie, A., Carlson, E.J., Epstein, C.J., Verkman, A.S. J. Biol. Chem. (1998)
- IL-13 effector functions. Wynn, T.A. Annu. Rev. Immunol. (2003)
- IgG Fc receptors. Ravetch, J.V., Bolland, S. Annu. Rev. Immunol. (2001)
- The biology of chemokines and their receptors. Rossi, D., Zlotnik, A. Annu. Rev. Immunol. (2000)
- Interleukin-1 receptor antagonist: role in biology. Arend, W.P., Malyak, M., Guthridge, C.J., Gabay, C. Annu. Rev. Immunol. (1998)
- Deletion of Peg10, an imprinted gene acquired from a retrotransposon, causes early embryonic lethality. Ono, R., Nakamura, K., Inoue, K., Naruse, M., Usami, T., Wakisaka-Saito, N., Hino, T., Suzuki-Migishima, R., Ogonuki, N., Miki, H., Kohda, T., Ogura, A., Yokoyama, M., Kaneko-Ishino, T., Ishino, F. Nat. Genet. (2006)
- Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response. Pasparakis, M., Alexopoulou, L., Episkopou, V., Kollias, G. J. Exp. Med. (1996)
- A macrophage invasion mechanism for mycobacteria implicating the extracellular domain of CD43. Fratazzi, C., Manjunath, N., Arbeit, R.D., Carini, C., Gerken, T.A., Ardman, B., Remold-O'Donnell, E., Remold, H.G. J. Exp. Med. (2000)
- Severe hypertriglyceridemia, reduced high density lipoprotein, and neonatal death in lipoprotein lipase knockout mice. Mild hypertriglyceridemia with impaired very low density lipoprotein clearance in heterozygotes. Weinstock, P.H., Bisgaier, C.L., Aalto-Setälä, K., Radner, H., Ramakrishnan, R., Levak-Frank, S., Essenburg, A.D., Zechner, R., Breslow, J.L. J. Clin. Invest. (1995)
- Conditional disruption of IkappaB kinase 2 fails to prevent obesity-induced insulin resistance. Röhl, M., Pasparakis, M., Baudler, S., Baumgartl, J., Gautam, D., Huth, M., De Lorenzi, R., Krone, W., Rajewsky, K., Brüning, J.C. J. Clin. Invest. (2004)
- Cholesterol 7-hydroxylase knockout mouse: a model for monohydroxy bile acid-related neonatal cholestasis. Arnon, R., Yoshimura, T., Reiss, A., Budai, K., Lefkowitch, J.H., Javitt, N.B. Gastroenterology (1998)
- Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Gunton, J.E., Kulkarni, R.N., Yim, S., Okada, T., Hawthorne, W.J., Tseng, Y.H., Roberson, R.S., Ricordi, C., O'Connell, P.J., Gonzalez, F.J., Kahn, C.R. Cell (2005)
- TGF-beta regulation by Emilin1: new links in the etiology of hypertension. Raman, M., Cobb, M.H. Cell (2006)
- A stimulatory role for cGMP-dependent protein kinase in platelet activation. Li, Z., Xi, X., Gu, M., Feil, R., Ye, R.D., Eigenthaler, M., Hofmann, F., Du, X. Cell (2003)
- GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes. Stenbit, A.E., Tsao, T.S., Li, J., Burcelin, R., Geenen, D.L., Factor, S.M., Houseknecht, K., Katz, E.B., Charron, M.J. Nat. Med. (1997)
- Leptin-regulated endocannabinoids are involved in maintaining food intake. Di Marzo, V., Goparaju, S.K., Wang, L., Liu, J., Bátkai, S., Járai, Z., Fezza, F., Miura, G.I., Palmiter, R.D., Sugiura, T., Kunos, G. Nature (2001)
- Tbx24, encoding a T-box protein, is mutated in the zebrafish somite-segmentation mutant fused somites. Nikaido, M., Kawakami, A., Sawada, A., Furutani-Seiki, M., Takeda, H., Araki, K. Nat. Genet. (2002)
- Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways. Lowin, B., Hahne, M., Mattmann, C., Tschopp, J. Nature (1994)
- Scrapie replication in lymphoid tissues depends on prion protein-expressing follicular dendritic cells. Brown, K.L., Stewart, K., Ritchie, D.L., Mabbott, N.A., Williams, A., Fraser, H., Morrison, W.I., Bruce, M.E. Nat. Med. (1999)
- T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation. Brewer, J.A., Khor, B., Vogt, S.K., Muglia, L.M., Fujiwara, H., Haegele, K.E., Sleckman, B.P., Muglia, L.J. Nat. Med. (2003)
- Specific deficit of the ON response in visual transmission by targeted disruption of the mGluR6 gene. Masu, M., Iwakabe, H., Tagawa, Y., Miyoshi, T., Yamashita, M., Fukuda, Y., Sasaki, H., Hiroi, K., Nakamura, Y., Shigemoto, R. Cell (1995)
- TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway. Dumitru, C.D., Ceci, J.D., Tsatsanis, C., Kontoyiannis, D., Stamatakis, K., Lin, J.H., Patriotis, C., Jenkins, N.A., Copeland, N.G., Kollias, G., Tsichlis, P.N. Cell (2000)
- A dominant complement fixation pathway for pneumococcal polysaccharides initiated by SIGN-R1 interacting with C1q. Kang, Y.S., Do, Y., Lee, H.K., Park, S.H., Cheong, C., Lynch, R.M., Loeffler, J.M., Steinman, R.M., Park, C.G. Cell (2006)
- Monoamine oxidase: from genes to behavior. Shih, J.C., Chen, K., Ridd, M.J. Annu. Rev. Neurosci. (1999)
- Inhibitory threshold for critical-period activation in primary visual cortex. Fagiolini, M., Hensch, T.K. Nature (2000)
- Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2. Trommsdorff, M., Gotthardt, M., Hiesberger, T., Shelton, J., Stockinger, W., Nimpf, J., Hammer, R.E., Richardson, J.A., Herz, J. Cell (1999)
- Female embryonic lethality in mice nullizygous for both Msh2 and p53. Cranston, A., Bocker, T., Reitmair, A., Palazzo, J., Wilson, T., Mak, T., Fishel, R. Nat. Genet. (1997)
- Magnitude of binocular vision controlled by islet-2 repression of a genetic program that specifies laterality of retinal axon pathfinding. Pak, W., Hindges, R., Lim, Y.S., Pfaff, S.L., O'Leary, D.D. Cell (2004)
- IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Holzenberger, M., Dupont, J., Ducos, B., Leneuve, P., Géloën, A., Even, P.C., Cervera, P., Le Bouc, Y. Nature (2003)
- Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis. Sharpless, N.E., Bardeesy, N., Lee, K.H., Carrasco, D., Castrillon, D.H., Aguirre, A.J., Wu, E.A., Horner, J.W., DePinho, R.A. Nature (2001)
- The absence of interleukin 9 does not affect the development of allergen-induced pulmonary inflammation nor airway hyperreactivity. McMillan, S.J., Bishop, B., Townsend, M.J., McKenzie, A.N., Lloyd, C.M. J. Exp. Med. (2002)
- HLA-A2.1-restricted education and cytolytic activity of CD8(+) T lymphocytes from beta2 microglobulin (beta2m) HLA-A2.1 monochain transgenic H-2Db beta2m double knockout mice. Pascolo, S., Bervas, N., Ure, J.M., Smith, A.G., Lemonnier, F.A., Pérarnau, B. J. Exp. Med. (1997)
- Glycine transporters: essential regulators of neurotransmission. Eulenburg, V., Armsen, W., Betz, H., Gomeza, J. Trends Biochem. Sci. (2005)
- Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase. Endres, M., Biniszkiewicz, D., Sobol, R.W., Harms, C., Ahmadi, M., Lipski, A., Katchanov, J., Mergenthaler, P., Dirnagl, U., Wilson, S.H., Meisel, A., Jaenisch, R. J. Clin. Invest. (2004)
- Cl- absorption across the thick ascending limb is not altered in cystic fibrosis mice. A role for a pseudo-CFTR Cl- channel. Marvão, P., De Jesus Ferreira, M.C., Bailly, C., Paulais, M., Bens, M., Guinamard, R., Moreau, R., Vandewalle, A., Teulon, J. J. Clin. Invest. (1998)