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MeSH Review

Mice, Knockout

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Disease relevance of Mice, Knockout


Psychiatry related information on Mice, Knockout


High impact information on Mice, Knockout

  • However, studies conducted with knockout mice, neutralizing antibodies, and novel antagonists demonstrate that IL-13 possesses several unique effector functions that distinguish it from IL-4 [11].
  • Since the description of the first mouse knockout for an IgG Fc receptor seven years ago, considerable progress has been made in defining the in vivo functions of these receptors in diverse biological systems [12].
  • Furthermore, an increase in the number of chemokine/receptor transgenic and knock-out mice has helped to define the functions of chemokines in vivo [13].
  • Studies in transgenic and knockout mice indicate that IL-1Ra is important in host defense against endotoxin-induced injury [14].
  • The Peg10 knockout mice showed early embryonic lethality owing to defects in the placenta [15].

Chemical compound and disease context of Mice, Knockout


Biological context of Mice, Knockout


Anatomical context of Mice, Knockout


Associations of Mice, Knockout with chemical compounds


Gene context of Mice, Knockout

  • Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2 [35].
  • Both Msh2- and p53-targeted knockout mice are viable and susceptible to cancer [36].
  • Isl2 knockout mice have an increased ipsilateral projection originating from significantly more RGCs limited to the VTC [37].
  • Here, using heterozygous knockout mice because null mutants are not viable, we report that Igf1r(+/-) mice live on average 26% longer than their wild-type littermates (P < 0.02) [38].
  • Overlapping reading frames in the INK4A/ARF gene encode p16INK4a and a distinct tumour-suppressor protein, p19ARF (ref. 3). Here we describe the generation and characterization of a p16Ink4a-specific knockout mouse that retains normal p19Arf function [39].

Analytical, diagnostic and therapeutic context of Mice, Knockout


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  16. Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response. Pasparakis, M., Alexopoulou, L., Episkopou, V., Kollias, G. J. Exp. Med. (1996) [Pubmed]
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  19. Conditional disruption of IkappaB kinase 2 fails to prevent obesity-induced insulin resistance. Röhl, M., Pasparakis, M., Baudler, S., Baumgartl, J., Gautam, D., Huth, M., De Lorenzi, R., Krone, W., Rajewsky, K., Brüning, J.C. J. Clin. Invest. (2004) [Pubmed]
  20. Cholesterol 7-hydroxylase knockout mouse: a model for monohydroxy bile acid-related neonatal cholestasis. Arnon, R., Yoshimura, T., Reiss, A., Budai, K., Lefkowitch, J.H., Javitt, N.B. Gastroenterology (1998) [Pubmed]
  21. Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Gunton, J.E., Kulkarni, R.N., Yim, S., Okada, T., Hawthorne, W.J., Tseng, Y.H., Roberson, R.S., Ricordi, C., O'Connell, P.J., Gonzalez, F.J., Kahn, C.R. Cell (2005) [Pubmed]
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  24. GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes. Stenbit, A.E., Tsao, T.S., Li, J., Burcelin, R., Geenen, D.L., Factor, S.M., Houseknecht, K., Katz, E.B., Charron, M.J. Nat. Med. (1997) [Pubmed]
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  26. Tbx24, encoding a T-box protein, is mutated in the zebrafish somite-segmentation mutant fused somites. Nikaido, M., Kawakami, A., Sawada, A., Furutani-Seiki, M., Takeda, H., Araki, K. Nat. Genet. (2002) [Pubmed]
  27. Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways. Lowin, B., Hahne, M., Mattmann, C., Tschopp, J. Nature (1994) [Pubmed]
  28. Scrapie replication in lymphoid tissues depends on prion protein-expressing follicular dendritic cells. Brown, K.L., Stewart, K., Ritchie, D.L., Mabbott, N.A., Williams, A., Fraser, H., Morrison, W.I., Bruce, M.E. Nat. Med. (1999) [Pubmed]
  29. T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation. Brewer, J.A., Khor, B., Vogt, S.K., Muglia, L.M., Fujiwara, H., Haegele, K.E., Sleckman, B.P., Muglia, L.J. Nat. Med. (2003) [Pubmed]
  30. Specific deficit of the ON response in visual transmission by targeted disruption of the mGluR6 gene. Masu, M., Iwakabe, H., Tagawa, Y., Miyoshi, T., Yamashita, M., Fukuda, Y., Sasaki, H., Hiroi, K., Nakamura, Y., Shigemoto, R. Cell (1995) [Pubmed]
  31. TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway. Dumitru, C.D., Ceci, J.D., Tsatsanis, C., Kontoyiannis, D., Stamatakis, K., Lin, J.H., Patriotis, C., Jenkins, N.A., Copeland, N.G., Kollias, G., Tsichlis, P.N. Cell (2000) [Pubmed]
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  34. Inhibitory threshold for critical-period activation in primary visual cortex. Fagiolini, M., Hensch, T.K. Nature (2000) [Pubmed]
  35. Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2. Trommsdorff, M., Gotthardt, M., Hiesberger, T., Shelton, J., Stockinger, W., Nimpf, J., Hammer, R.E., Richardson, J.A., Herz, J. Cell (1999) [Pubmed]
  36. Female embryonic lethality in mice nullizygous for both Msh2 and p53. Cranston, A., Bocker, T., Reitmair, A., Palazzo, J., Wilson, T., Mak, T., Fishel, R. Nat. Genet. (1997) [Pubmed]
  37. Magnitude of binocular vision controlled by islet-2 repression of a genetic program that specifies laterality of retinal axon pathfinding. Pak, W., Hindges, R., Lim, Y.S., Pfaff, S.L., O'Leary, D.D. Cell (2004) [Pubmed]
  38. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Holzenberger, M., Dupont, J., Ducos, B., Leneuve, P., Géloën, A., Even, P.C., Cervera, P., Le Bouc, Y. Nature (2003) [Pubmed]
  39. Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis. Sharpless, N.E., Bardeesy, N., Lee, K.H., Carrasco, D., Castrillon, D.H., Aguirre, A.J., Wu, E.A., Horner, J.W., DePinho, R.A. Nature (2001) [Pubmed]
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  44. Cl- absorption across the thick ascending limb is not altered in cystic fibrosis mice. A role for a pseudo-CFTR Cl- channel. Marvão, P., De Jesus Ferreira, M.C., Bailly, C., Paulais, M., Bens, M., Guinamard, R., Moreau, R., Vandewalle, A., Teulon, J. J. Clin. Invest. (1998) [Pubmed]
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