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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

KLRC3  -  killer cell lectin-like receptor subfamily...

Homo sapiens

Synonyms: NK cell receptor E, NKG2-E, NKG2-E type II integral membrane protein, NKG2-E-activating NK receptor, NKG2E
 
 
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High impact information on KLRC3

  • Developing NK cells express first CD94, then NKG2A, NKG2E, and finally NKG2C [1].
  • NKG2H protein represents an alternative spliced form of the NKG2E gene, displaying a charged residue in the transmembrane portion and a cytoplasmic tail that lacks immunoreceptor tyrosine-based inhibitory motifs [2].
  • More importantly, and corroborated with their cytolytic activities, the NK receptors genes, NKG2C and NKG2E, together with perforin, were upregulated exclusively in CIK cells that were cytolytic to susceptible AML targets [3].
 

Biological context of KLRC3

  • We show that NKG2C consists of six exons, whereas NKG2E has seven, and the splice acceptor site for the seventh exon occurs in an Alu repeat [4].

References

  1. CD94 transcripts imply a better prognosis in nasal-type extranodal NK/T-cell lymphoma. Lin, C.W., Chen, Y.H., Chuang, Y.C., Liu, T.Y., Hsu, S.M. Blood (2003) [Pubmed]
  2. Triggering of effector functions on a CD8+ T cell clone upon the aggregation of an activatory CD94/kp39 heterodimer. Bellón, T., Heredia, A.B., Llano, M., Minguela, A., Rodriguez, A., López-Botet, M., Aparicio, P. J. Immunol. (1999) [Pubmed]
  3. Comparative gene expression profiling of cytokine-induced killer cells in response to acute myloid leukemic and acute lymphoblastic leukemic stimulators using oligonucleotide arrays. Linn, Y.C., Wang, S.M., Hui, K.M. Exp. Hematol. (2005) [Pubmed]
  4. The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex. Glienke, J., Sobanov, Y., Brostjan, C., Steffens, C., Nguyen, C., Lehrach, H., Hofer, E., Francis, F. Immunogenetics (1998) [Pubmed]
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