Gene Review:
KLRC1 - killer cell lectin-like receptor subfamily...
Homo sapiens
Synonyms:
CD159 antigen-like family member A, CD159A, CD159a, NK cell receptor A, NKG2, ...
Speiser,
Pittet,
Valmori,
Dunbar,
Rimoldi,
Liénard,
MacDonald,
Cerottini,
Cerundolo,
Romero,
Plougastel,
Trowsdale,
Warren,
Christiansen,
Witt,
Borrego,
Kabat,
Sanni,
Coligan,
Plougastel,
Trowsdale,
Braud,
Allan,
O'Callaghan,
Söderström,
D'Andrea,
Ogg,
Lazetic,
Young,
Bell,
Phillips,
Lanier,
McMichael,
Nguyen,
Dhedin,
Vernant,
Kuentz,
Al Jijakli,
Rouas-Freiss,
Carosella,
Boudifa,
Debré,
Vieillard,
- Variations of human killer cell lectin-like receptors: common occurrence of NKG2-C deletion in the general population. Hikami, K., Tsuchiya, N., Yabe, T., Tokunaga, K. Genes Immun. (2003)
- Negative regulation of NK cell activities by inhibitory receptor CD94/NKG2A leads to altered NK cell-induced modulation of dendritic cell functions in chronic hepatitis C virus infection. Jinushi, M., Takehara, T., Tatsumi, T., Kanto, T., Miyagi, T., Suzuki, T., Kanazawa, Y., Hiramatsu, N., Hayashi, N. J. Immunol. (2004)
- Differential expression of inhibitory or activating CD94/NKG2 subtypes on MART-1-reactive T cells in vitiligo versus melanoma: a case report. Pedersen, L.Ø., Vetter, C.S., Mingari, M.C., Andersen, M.H., thor Straten, P., Bröcker, E.B., Becker, J.C. J. Invest. Dermatol. (2002)
- Functional inhibitory human leucocyte antigen class I receptors on natural killer (NK) cells in patients with chronic NK lymphocytosis. Warren, H.S., Christiansen, F.T., Witt, C.S. Br. J. Haematol. (2003)
- IFN-gamma protects short-term ovarian carcinoma cell lines from CTL lysis via a CD94/NKG2A-dependent mechanism. Malmberg, K.J., Levitsky, V., Norell, H., de Matos, C.T., Carlsten, M., Schedvins, K., Rabbani, H., Moretta, A., Söderström, K., Levitskaya, J., Kiessling, R. J. Clin. Invest. (2002)
- The specific regulation of immune responses by CD8+ T cells restricted by the MHC class Ib molecule, Qa-1. Jiang, H., Chess, L. Annu. Rev. Immunol. (2000)
- HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C. Braud, V.M., Allan, D.S., O'Callaghan, C.A., Söderström, K., D'Andrea, A., Ogg, G.S., Lazetic, S., Young, N.T., Bell, J.I., Phillips, J.H., Lanier, L.L., McMichael, A.J. Nature (1998)
- Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E. O'Callaghan, C.A., Tormo, J., Willcox, B.E., Braud, V.M., Jakobsen, B.K., Stuart, D.I., McMichael, A.J., Bell, J.I., Jones, E.Y. Mol. Cell (1998)
- In vivo expression of natural killer cell inhibitory receptors by human melanoma-specific cytolytic T lymphocytes. Speiser, D.E., Pittet, M.J., Valmori, D., Dunbar, R., Rimoldi, D., Liénard, D., MacDonald, H.R., Cerottini, J.C., Cerundolo, V., Romero, P. J. Exp. Med. (1999)
- NKG2A complexed with CD94 defines a novel inhibitory natural killer cell receptor. Brooks, A.G., Posch, P.E., Scorzelli, C.J., Borrego, F., Coligan, J.E. J. Exp. Med. (1997)
- DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. Houchins, J.P., Yabe, T., McSherry, C., Bach, F.H. J. Exp. Med. (1991)
- Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes. Plougastel, B., Trowsdale, J. Genomics (1998)
- A signal peptide derived from hsp60 binds HLA-E and interferes with CD94/NKG2A recognition. Michaëlsson, J., Teixeira de Matos, C., Achour, A., Lanier, L.L., Kärre, K., Söderström, K. J. Exp. Med. (2002)
- Orderly and nonstochastic acquisition of CD94/NKG2 receptors by developing NK cells derived from embryonic stem cells in vitro. Lian, R.H., Maeda, M., Lohwasser, S., Delcommenne, M., Nakano, T., Vance, R.E., Raulet, D.H., Takei, F. J. Immunol. (2002)
- Recognition of human histocompatibility leukocyte antigen (HLA)-E complexed with HLA class I signal sequence-derived peptides by CD94/NKG2 confers protection from natural killer cell-mediated lysis. Borrego, F., Ulbrecht, M., Weiss, E.H., Coligan, J.E., Brooks, A.G. J. Exp. Med. (1998)
- NK cell CD94/NKG2A inhibitory receptors are internalized and recycle independently of inhibitory signaling processes. Borrego, F., Kabat, J., Sanni, T.B., Coligan, J.E. J. Immunol. (2002)
- Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits. Lazetic, S., Chang, C., Houchins, J.P., Lanier, L.L., Phillips, J.H. J. Immunol. (1996)
- Inhibition of antigen-induced T cell response and antibody-induced NK cell cytotoxicity by NKG2A: association of NKG2A with SHP-1 and SHP-2 protein-tyrosine phosphatases. Le Dréan, E., Vély, F., Olcese, L., Cambiaggi, A., Guia, S., Krystal, G., Gervois, N., Moretta, A., Jotereau, F., Vivier, E. Eur. J. Immunol. (1998)
- The CD94/NKG2 C-type lectin receptor complex: involvement in NK cell-mediated recognition of HLA class I molecules. López-Botet, M., Carretero, M., Pérez-Villar, J., Bellón, T., Llano, M., Navarro, F. Immunol. Res. (1997)
- Role that each NKG2A immunoreceptor tyrosine-based inhibitory motif plays in mediating the human CD94/NKG2A inhibitory signal. Kabat, J., Borrego, F., Brooks, A., Coligan, J.E. J. Immunol. (2002)
- Cutting Edge: Distinct NK Receptor Profiles Are Imprinted on CD8 T Cells in the Mucosa and Periphery during the Same Antigen Challenge: Role of Tissue-Specific Factors. Laouar, A., Manocha, M., Wan, M., Yagita, H., van Lier, R.A., N, M. J. Immunol. (2007)
- The human CD94 gene encodes multiple, expressible transcripts including a new partner of NKG2A/B. Lieto, L.D., Maasho, K., West, D., Borrego, F., Coligan, J.E. Genes Immun. (2006)
- Kinetics and peptide dependency of the binding of the inhibitory NK receptor CD94/NKG2-A and the activating receptor CD94/NKG2-C to HLA-E. Valés-Gómez, M., Reyburn, H.T., Erskine, R.A., López-Botet, M., Strominger, J.L. EMBO J. (1999)
- GATA-3 is an important transcription factor for regulating human NKG2A gene expression. Marusina, A.I., Kim, D.K., Lieto, L.D., Borrego, F., Coligan, J.E. J. Immunol. (2005)
- A multigene family on human chromosome 12 encodes natural killer-cell lectins. Yabe, T., McSherry, C., Bach, F.H., Fisch, P., Schall, R.P., Sondel, P.M., Houchins, J.P. Immunogenetics (1993)
- The role of CD94/NKG2 in innate and adaptive immunity. Gunturi, A., Berg, R.E., Forman, J. Immunol. Res. (2004)
- HLA-E is a major ligand for the natural killer inhibitory receptor CD94/NKG2A. Lee, N., Llano, M., Carretero, M., Ishitani, A., Navarro, F., López-Botet, M., Geraghty, D.E. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Opposing effect of IFNgamma and IFNalpha on expression of NKG2 receptors: negative regulation of IFNgamma on NK cells. Zhang, C., Zhang, J., Sun, R., Feng, J., Wei, H., Tian, Z. Int. Immunopharmacol. (2005)
- Cloning of NKG2-F, a new member of the NKG2 family of human natural killer cell receptor genes. Plougastel, B., Trowsdale, J. Eur. J. Immunol. (1997)
- Differential expression of inhibitory and activating CD94/NKG2 receptors on NK cell clones. Brostjan, C., Bellón, T., Sobanov, Y., López-Botet, M., Hofer, E. J. Immunol. Methods (2002)
- Role for NKG2-A and NKG2-C surface receptors in chronic CD4+ T-cell responses. Ortega, C., Romero, P., Palma, A., Orta, T., Peña, J., García-Vinuesa, A., Molina, I.J., Santamaría, M. Immunol. Cell Biol. (2004)
- The human natural killer gene complex is located on chromosome 12p12-p13. Renedo, M., Arce, I., Rodríguez, A., Carretero, M., Lanier, L.L., López-Botet, M., Fernández-Ruiz, E. Immunogenetics (1997)
- NK-cell reconstitution after haploidentical hematopoietic stem-cell transplantations: immaturity of NK cells and inhibitory effect of NKG2A override GvL effect. Nguyen, S., Dhedin, N., Vernant, J.P., Kuentz, M., Al Jijakli, A., Rouas-Freiss, N., Carosella, E.D., Boudifa, A., Debré, P., Vieillard, V. Blood (2005)
- The activating form of CD94 receptor complex: CD94 covalently associates with the Kp39 protein that represents the product of the NKG2-C gene. Cantoni, C., Biassoni, R., Pende, D., Sivori, S., Accame, L., Pareti, L., Semenzato, G., Moretta, L., Moretta, A., Bottino, C. Eur. J. Immunol. (1998)
- Effect of tumor growth factor-beta on NK receptor expression by allostimulated CD8+ T lymphocytes. Guerra, N., Benlhassan, K., Carayol, G., Guillard, M., Pardoux, C., Chouaib, S., Caignard, A. Eur. Cytokine Netw. (1999)