Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Sly - Sycp3 like Y-linked

Mus musculus

Hurt, J.D. et al., Eto, Y. et al.

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Disease relevance of Sly

A cDNA encoding the murine carbonic anhydrase IV (mCA IV) gene, modified to resemble a form of mature human carbonic anhydrase IV (Okuyama, T., Waheed, A., Kusumoto, W., Zhu, X. L., and Sly, W. S. (1995) Arch. Biochem. Biophys. 320, 315-322), was expressed in Escherichia coli [1].
For in vivo gene therapy, we produced a recombinant adenovirus that expresses human beta-glucuronidase and administered this to Sly mice intravenously [2].

High impact information on Sly

Furthermore, the macrophages from Sly mice were treated with retrovirus/adenovirus vector expressing HBG activity and the glycosaminoglycan accumulation was markedly decreased after 5 weeks [2].

References

Catalytic properties of murine carbonic anhydrase IV. Hurt, J.D., Tu, C., Laipis, P.J., Silverman, D.N. J. Biol. Chem. (1997) [Pubmed]
Gene therapy/cell therapy for lysosomal storage disease. Eto, Y., Ohashi, T. J. Inherit. Metab. Dis. (2000) [Pubmed]

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