Gene Review:
Mthfr-ps1 - 5,10-methylenetetrahydrofolate reductase,...
Mus musculus
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High impact information on Mthfr-ps1
- Investigations of the Mthfr gene should take into account the presence of the non-functional Mthfr-ps to avoid misinterpretation of results [1].
Biological context of Mthfr-ps1
- The absence of intron 1, the partial retention of intron 2, the location of this gene on chromosome 5, and the presence of sequences unrelated to Mthfr at the 5' and 3' ends of the 1259 bp fragment are features that are indicative of a partially-processed pseudogene, that we have designated Mthfr-ps [1].
Analytical, diagnostic and therapeutic context of Mthfr-ps1
- A Mthfr-ps transcript was not detectable by sensitive RT-PCR using assays designed to simultaneously detect the authentic Mthfr transcript [1].
References
- Characterization of a pseudogene for murine methylenetetrahydrofolate reductase. Leclerc, D., Darwich-Codore, H., Rozen, R. Mol. Cell. Biochem. (2003) [Pubmed]
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