Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

KNG1 - kininogen 1

Sus scrofa

Scuri, M. et al., Imamura, T. et al.

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High impact information on KNG

Incubation of tryptase with high or low molecular weight kininogen induced VPE activity in a dose- and incubation time-dependent manner [1].
TK has been identified as the major kininogenase of the airway and cleaves both high- and low-molecular weight kininogen to yield lysyl-bradykinin [2].

References

Induction of vascular permeability enhancement by human tryptase: dependence on activation of prekallikrein and direct release of bradykinin from kininogens. Imamura, T., Dubin, A., Moore, W., Tanaka, R., Travis, J. Lab. Invest. (1996) [Pubmed]
Inhaled porcine pancreatic elastase causes bronchoconstriction via a bradykinin-mediated mechanism. Scuri, M., Forteza, R., Lauredo, I., Sabater, J.R., Botvinnikova, Y., Allegra, L., Abraham, W.M. J. Appl. Physiol. (2000) [Pubmed]

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