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Chemical Compound Review

KALLIDIN     2-[[2-[[1-[2-[[2-[2-[[1-[1- [2-(2,6...

Synonyms: Lys-Bradykinin, AR-1J3549, LS-174455, AC1L1TC1, AC1Q5KW7, ...
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Disease relevance of KALLIDIN


High impact information on KALLIDIN

  • The antibodies were isotyped as IgG1, kappa-type, and their target epitopes mapped with bradykinin, lysyl-bradykinin (kallidin), kinin receptor antagonists, and fragments thereof, revealing three distinct sets of mAb, i.e., mAb against bradykinin (MBK)1, MBK2, and MBK3 [4].
  • The activity of the aminopeptidase against its synthetic substrate was also inhibited by lysylbradykinin (IC50 = 50 microM) [5].
  • Electrogenic ion transport can be stimulated by the beta-adrenergic agonist isoproterenol (10(-6) M) and by lysylbradykinin (10(-7) M) but not by the cholinergic agonist carbachol at 10(-6) M) [6].
  • High molecular weight Kgn and low molecular weight Kgn were both diminished in MH (0.26 +/- 0.04 nmol bradykinin/ml and 0.93 +/- 0.12 nmol lysyl-bradykinin/ml, respectively) as compared to NC (0.39 +/- 0.07 and 1.92 +/- 0.16) and EH (0.51 +/- 0.07 and 1.65 +/- 0.13) [7].
  • We have synthesized internally quenched peptides spanning the Met379-Lys380 or Arg389-Ser390 bonds of human kininogen (hkng) that flank lysyl-bradykinin and have studied the kinetics of their hydrolysis by human tissue kallikrein [8].

Biological context of KALLIDIN


Anatomical context of KALLIDIN


Associations of KALLIDIN with other chemical compounds

  • 2. Measurements of electrogenic chloride secretion (as short circuit current), and of intracellular Ca2+ (from Fura-2 fluorescence) were used to assess the action of lysylbradykinin in the absence and presence of Hoe 140 [15].
  • A cultured human epithelial cell line, Colony 29, has been used to investigate the relation between anion secretion and intracellular Ca2+ concentration (Cai) in response to the secretagogues, lysylbradykinin (LBk) and histamine [18].
  • These enzymes release the vasoactive peptides angiotensin II and lysyl-bradykinin from the precursors angiotensinogen and kininogen, respectively [19].
  • The effect of the kinin, kallidin (lysyl-bradykinin) on phosphoinositide metabolism and prolactin secretion was examined in male rat anterior pituitary cells in primary culture [20].
  • Unexpectedly, MBP hydrolyzed lysyl-bradykinin and methionyl-lysyl-bradykinin at the carboxyl side of Gly fairly specifically and efficiently displaying a unique cleavage [21].

Gene context of KALLIDIN


Analytical, diagnostic and therapeutic context of KALLIDIN


  1. Concentrations of glandular kallikrein in human nasal secretions increase during experimentally induced allergic rhinitis. Baumgarten, C.R., Nichols, R.C., Naclerio, R.M., Proud, D. J. Immunol. (1986) [Pubmed]
  2. Kinin effects on ion transport in monolayers of HCA-7 cells, a line from a human colonic adenocarcinoma. Cuthbert, A.W., Kirkland, S.C., MacVinish, L.J. Br. J. Pharmacol. (1985) [Pubmed]
  3. Urinary kinin excretion following alterations of vasopressin levels in man and rat. Náray-Fejes-Tóth, A., Fejes-Tóth, G. Renal physiology. (1986) [Pubmed]
  4. Anti-idiotypic antibodies bearing the internal image of a bradykinin epitope. Production, characterization, and interaction with the kinin receptor. Haasemann, M., Buschko, J., Faussner, A., Roscher, A.A., Hoebeke, J., Burch, R.M., Müller-Esterl, W. J. Immunol. (1991) [Pubmed]
  5. Kinin metabolism in human nasal secretions during experimentally induced allergic rhinitis. Proud, D., Baumgarten, C.R., Naclerio, R.M., Ward, P.E. J. Immunol. (1987) [Pubmed]
  6. NCL-SG3: a human eccrine sweat gland cell line that retains the capacity for transepithelial ion transport. Lee, C.M., Dessi, J. J. Cell. Sci. (1989) [Pubmed]
  7. Malignant hypertension: a syndrome accompanied by plasmatic diminution of low and high molecular weight kininogens. Ribeiro, A.B., Schwarzwalder, S.R., Saragoça, M.A., Almeida, F.A., Voos, A., Stella, R.C., Ramos, O.L. Hypertension (1983) [Pubmed]
  8. Evaluation of the extent of the binding site in human tissue kallikrein by synthetic substrates with sequences of human kininogen fragments. Del Nery, E., Chagas, J.R., Juliano, M.A., Prado, E.S., Juliano, L. Biochem. J. (1995) [Pubmed]
  9. Angiotensin I converting enzyme and kinin-hydrolyzing enzymes along the rabbit nephron. Marchetti, J., Roseau, S., Alhenc-Gelas, F. Kidney Int. (1987) [Pubmed]
  10. Participation of the kallikrein-kinin-receptor system in reflexes arising from neural afferents in the dog epicardium. Staszewska-Woolley, J., Woolley, G. J. Physiol. (Lond.) (1989) [Pubmed]
  11. Purification of a vasoactive peptide related to lysyl-bradykinin from trout plasma. Conlon, J.M., Olson, K.R. FEBS Lett. (1993) [Pubmed]
  12. Renal vasoconstrictive effect of kinins mediated by B1-kinin receptors. Guimarães, J.A., Vieira, M.A., Camargo, M.J., Maack, T. Eur. J. Pharmacol. (1986) [Pubmed]
  13. Peptidase inhibitors potentiate lysylbradykinin-induced bronchoconstriction in the rat. Schilero, G.J., Almenoff, P., Lesser, M., Cardozo, C. Regul. Pept. (1996) [Pubmed]
  14. Human eccrine sweat gland epithelial cultures express ductal characteristics. Brayden, D.J., Cuthbert, A.W., Lee, C.M. J. Physiol. (Lond.) (1988) [Pubmed]
  15. Antagonism of kinin effects on epithelial by Hoe 140: apparently competitive and non-competitive interactions. Cuthbert, A.W., MacVinish, L.J., Pickles, R.J. Br. J. Pharmacol. (1992) [Pubmed]
  16. Activation of ion channels by lysylbradykinin in the HCA-7 colony 29 human adenocarcinoma cell line. Henderson, R.M., Cuthbert, A.W. Br. J. Pharmacol. (1993) [Pubmed]
  17. Neutral endopeptidase and angiotensin converting enzyme inhibitors potentiate kinin-induced contraction of ferret trachea. Dusser, D.J., Nadel, J.A., Sekizawa, K., Graf, P.D., Borson, D.B. J. Pharmacol. Exp. Ther. (1988) [Pubmed]
  18. Relation of anion secretory activity to intracellular Ca2+ in response to lysylbradykinin and histamine in a cultured human colonic epithelium. Pickles, R.J., Cuthbert, A.W. Eur. J. Pharmacol. (1991) [Pubmed]
  19. Immunohistochemical localization of tonin and its relation to kallikrein in rat salivary glands. Orstavik, T.B., Carretero, O.A., Hayashi, H., Scicli, G.A., Johansen, L. J. Histochem. Cytochem. (1982) [Pubmed]
  20. Kallidin-induced stimulation of inositol phosphate production and prolactin release in rat anterior pituitary cells. Jones, T.H., Brown, B.L., Dobson, P.R. Acta Endocrinol. (1990) [Pubmed]
  21. Cleavage specificity of a myofibril-bound serine proteinase from carp (Cyprinus carpio) muscle. Cao, M.J., Osatomi, K., Pangkey, H., Hara, K., Ishihara, T. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (1999) [Pubmed]
  22. Limited proteolysis of human low-molecular-mass kininogen by tissue kallikrein. Isolation and characterization of the heavy and the light chains. Müller-Esterl, W., Rauth, G., Lottspeich, F., Kellermann, J., Henschen, A. Eur. J. Biochem. (1985) [Pubmed]
  23. Inhaled porcine pancreatic elastase causes bronchoconstriction via a bradykinin-mediated mechanism. Scuri, M., Forteza, R., Lauredo, I., Sabater, J.R., Botvinnikova, Y., Allegra, L., Abraham, W.M. J. Appl. Physiol. (2000) [Pubmed]
  24. Degradation of lysylbradykinin by endopeptidase 24.11 and endopeptidase 24.15. Rosenbaum, C., Cardozo, C., Lesser, M. Peptides (1995) [Pubmed]
  25. Kinin release from kininogens by calpains. Higashiyama, S., Ishiguro, H., Ohkubo, I., Fujimoto, S., Matsuda, T., Sasaki, M. Life Sci. (1986) [Pubmed]
  26. Action of human pancreas alanine aminopeptidase on biologically active peptides: kinin converting activity. Sidorowicz, W., Zownir, O., Behal, F.J. Clin. Chim. Acta (1981) [Pubmed]
  27. Cell-cell interaction underlies formation of fluid in the male reproductive tract of the rat. Cheung, K.H., Leung, G.P., Leung, M.C., Shum, W.W., Zhou, W.L., Wong, P.Y. J. Gen. Physiol. (2005) [Pubmed]
  28. Circulating bradykinin-like immunoreactivity and the pentagastrin-induced carcinoid flush. Balks, H.J., Conlon, J.M., Creutzfeldt, W., Stöckmann, F. Clin. Endocrinol. (Oxf) (1988) [Pubmed]
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