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Gene Review:

ACADS - acyl-CoA dehydrogenase, C-2 to C-3 short...

Sus scrofa

DuPlessis, E.R. et al., Lundberg, N.N. et al., Djordjevic, S. et al.

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Disease relevance of ACADS

The relatively high oxidase activity of the short chain acyl-CoA dehydrogenase from the obligate anaerobe Megasphaera elsdenii was studied by rapid reaction kinetics of wild-type and the Glu367-Gln mutant using butyryl-, crotonyl-, and 2-aza-butyryl-CoA thioesters [1].

High impact information on ACADS

BCAD is a bacterial analog of short chain acyl-CoA dehydrogenase from mammalian mitochondria [2].
2-Pentynoyl-CoA is a mechanism-based inactivator of the flavoprotein short-chain acyl-CoA dehydrogenase from pig liver [3].

References

Oxidase activity of the acyl-CoA dehydrogenases. DuPlessis, E.R., Pellett, J., Stankovich, M.T., Thorpe, C. Biochemistry (1998) [Pubmed]
Three-dimensional structure of butyryl-CoA dehydrogenase from Megasphaera elsdenii. Djordjevic, S., Pace, C.P., Stankovich, M.T., Kim, J.J. Biochemistry (1995) [Pubmed]
Inactivation of short-chain acyl-coenzyme A dehydrogenase from pig liver by 2-pentynoyl-coenzyme A. Lundberg, N.N., Thorpe, C. Arch. Biochem. Biophys. (1993) [Pubmed]

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