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Gene Review

PIAP  -  inhibitor of apoptosis-like

Sus scrofa

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Disease relevance of PIAP

  • We demonstrate that adenovirus mediated overexpression of I kappa B alpha, an inhibitor of NF-kappa B suppresses the expression of piap in response to TNF-alpha suggesting that piap is one of the NF-kappa B regulated genes that operates to prevent programmed cell death of EC in inflammation [1].

High impact information on PIAP

  • By differential screening we have identified a cDNA clone, designated piap, in porcine aortic endothelial cells (PAEC) that turned out by sequence comparison to be a porcine member of the iap family [1].


  1. Cytokine induced expression of porcine inhibitor of apoptosis protein (iap) family member is regulated by NF-kappa B. Stehlik, C., de Martin, R., Binder, B.R., Lipp, J. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
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