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Gene Review:

PTH1R - parathyroid hormone 1 receptor

Sus scrofa

Synonyms: PTH, PTHR1

Zierold, C. et al., Hayes, G. et al., Shimizu, N. et al.

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High impact information on PTHR1

To study the mechanism of PTH action, we used AOK-B50 cells, a porcine kidney-cell line with stably transfected opossum PTH receptor in which both the 24-hydroxylase mRNA and activity are down-regulated by PTH [1].
Immunocytochemistry suggests an apical and basolateral localization of the transfected PTH receptor in LLC-PK1 cells and only a basolateral localization in MDCK cells [2].

Other interactions of PTHR1

The new analogs presented should be useful as minimum-length functional probes of the PTH-PTH receptor interaction mechanism [3].

References

Parathyroid hormone regulates 25-hydroxyvitamin D(3)-24-hydroxylase mRNA by altering its stability. Zierold, C., Mings, J.A., DeLuca, H.F. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
Expression of parathyroid hormone receptors in MDCK and LLC-PK1 cells. Hayes, G., Forgo, J., Bringhurst, F.R., Segre, G., Murer, H. Pflugers Arch. (1995) [Pubmed]
Amino-terminal parathyroid hormone fragment analogs containing alpha,alpha-di-alkyl amino acids at positions 1 and 3. Shimizu, N., Dean, T., Khatri, A., Gardella, T.J. J. Bone Miner. Res. (2004) [Pubmed]

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