Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

gli2 - GLI family zinc finger 2

Xenopus laevis

Takabatake, Y. et al., Brewster, R. et al., Ruiz i Altaba, A.

Ruiz i Altaba,

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High impact information on Gli2

Moreover, the homeobox gene Xhox3, a critical determinant of posterior development, is also directly regulated by Gli2 [1].
Gli3, but not Gli1, has an activity similar to that of Gli2 and is expressed in ventroposterior mesoderm after Gli2 [1].
In addition, Gli3 inhibits motor neuron differentiation by Gli2 [2].
Indeed, Tbx2/3 misexpression suppressed Gli1, Gli2, Ptc2 and Pax2, mediators or targets of Hedgehog (Hh) signals [3].

References

Gli2 functions in FGF signaling during antero-posterior patterning. Brewster, R., Mullor, J.L., Ruiz i Altaba, A. Development (2000) [Pubmed]
Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog. Ruiz i Altaba, A. Development (1998) [Pubmed]
Conserved expression control and shared activity between cognate T-box genes Tbx2 and Tbx3 in connection with Sonic hedgehog signaling during Xenopus eye development. Takabatake, Y., Takabatake, T., Sasagawa, S., Takeshima, K. Dev. Growth Differ. (2002) [Pubmed]

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