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Gene Review:

umuD - DNA polymerase V subunit UmuD

Escherichia coli UTI89

Hare, J.M. et al., Beuning, P.J. et al.

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Disease relevance of umuD

Escherichia coli possesses two members of the Y family, DNA pol IV (DinB) and DNA pol V (UmuD'(2)C), and several regulatory factors, including those encoded by the umuD gene that influence the activity of UmuC [1].

High impact information on umuD

The umuD mutation did not affect the growth rate or survival after UV-induced DNA damage [2].
The umuD open reading frame is intact, but it is 1.5 times the size of other umuD genes and has an extra 5' region that lacks homology to known umuD genes [2].

References

Characterization of Escherichia coli translesion synthesis polymerases and their accessory factors. Beuning, P.J., Simon, S.M., Godoy, V.G., Jarosz, D.F., Walker, G.C. Meth. Enzymol. (2006) [Pubmed]
A constitutively expressed, truncated umuDC operon regulates the recA-dependent DNA damage induction of a gene in Acinetobacter baylyi strain ADP1. Hare, J.M., Perkins, S.N., Gregg-Jolly, L.A. Appl. Environ. Microbiol. (2006) [Pubmed]

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