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Gene Review

umuC  -  DNA polymerase V subunit UmuC

Escherichia coli UTI89

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Disease relevance of umuC

  • Escherichia coli possesses two members of the Y family, DNA pol IV (DinB) and DNA pol V (UmuD'(2)C), and several regulatory factors, including those encoded by the umuD gene that influence the activity of UmuC [1].
  • Additionally, these activated RecA columns have been used to investigate binding interactions of phage lambda repressor, as well as the UmuC protein, which is required for chemical mutagenesis [2].

High impact information on umuC


Biological context of umuC


Associations of umuC with chemical compounds

  • Since both 9-aminoacridine and ICR191 mutagenesis of these strains is independent of the recA+ and lexA+ gene products, these results may suggest a broader role for the UmuC protein in regulating induced mutation frequencies than has previously been suspected [12].

Other interactions of umuC

  • The results are interpreted in terms of a revised model in which UmuC protein is envisaged as guiding UmuD' to RecA protein which has recognized and become bound to an appropriate DNA lesion [13].


  1. Characterization of Escherichia coli translesion synthesis polymerases and their accessory factors. Beuning, P.J., Simon, S.M., Godoy, V.G., Jarosz, D.F., Walker, G.C. Meth. Enzymol. (2006) [Pubmed]
  2. "Activated"-RecA protein affinity chromatography of LexA repressor and other SOS-regulated proteins. Freitag, N., McEntee, K. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  3. Biochemical basis of SOS-induced mutagenesis in Escherichia coli: reconstitution of in vitro lesion bypass dependent on the UmuD'2C mutagenic complex and RecA protein. Tang, M., Bruck, I., Eritja, R., Turner, J., Frank, E.G., Woodgate, R., O'Donnell, M., Goodman, M.F. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  4. Cloning and genetic analysis of the UV resistance determinant (uvr) encoded on the Enterococcus faecalis pheromone-responsive conjugative plasmid pAD1. Ozawa, Y., Tanimoto, K., Fujimoto, S., Tomita, H., Ike, Y. J. Bacteriol. (1997) [Pubmed]
  5. Isolation and characterization of novel plasmid-encoded umuC mutants. Woodgate, R., Singh, M., Kulaeva, O.I., Frank, E.G., Levine, A.S., Koch, W.H. J. Bacteriol. (1994) [Pubmed]
  6. Deletion of the Saccharomyces cerevisiae gene RAD30 encoding an Escherichia coli DinB homolog confers UV radiation sensitivity and altered mutability. Roush, A.A., Suarez, M., Friedberg, E.C., Radman, M., Siede, W. Mol. Gen. Genet. (1998) [Pubmed]
  7. Genetic analysis of the anti-mutagenic effect of genistein in Escherichia coli. Yang, Y., Fix, D. Mutat. Res. (2006) [Pubmed]
  8. Multiple pathways for SOS-induced mutagenesis in Escherichia coli: an overexpression of dinB/dinP results in strongly enhancing mutagenesis in the absence of any exogenous treatment to damage DNA. Kim, S.R., Maenhaut-Michel, G., Yamada, M., Yamamoto, Y., Matsui, K., Sofuni, T., Nohmi, T., Ohmori, H. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  9. Escherichia coli umuDC mutants: DNA sequence alterations and UmuD cleavage. Koch, W.H., Ennis, D.G., Levine, A.S., Woodgate, R. Mol. Gen. Genet. (1992) [Pubmed]
  10. Analysis of chimeric UmuC proteins: identification of regions in Salmonella typhimurium UmuC important for mutagenic activity. Koch, W.H., Kopsidas, G., Meffle, B., Levine, A.S., Woodgate, R. Mol. Gen. Genet. (1996) [Pubmed]
  11. A model for the structure of the Escherichia coli SOS-regulated UmuD2 protein. Sutton, M.D., Guzzo, A., Narumi, I., Costanzo, M., Altenbach, C., Ferentz, A.E., Hubbell, W.L., Walker, G.C. DNA Repair (Amst.) (2002) [Pubmed]
  12. RecA-independent mutagenesis in Escherichia coli: effects of umuC and mucB mutations. Thomas, S.M., MacPhee, D.G. Mutagenesis (1986) [Pubmed]
  13. Mutagenic DNA repair in Escherichia coli, XX. Overproduction of UmuD' protein results in suppression of the umuC36 mutation in excision defective bacteria. Bates, H., Bridges, B.A., Woodgate, R. Mutat. Res. (1991) [Pubmed]
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