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Gene Review

holE  -  DNA polymerase III subunit theta

Escherichia coli UTI89

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Disease relevance of holE

  • The Hot (homolog of theta) protein of bacteriophage P1 can substitute for the Escherichia coli DNA polymerase III theta subunit, as evidenced by its stabilizing effect on certain dnaQ mutants that carry an unstable polymerase III epsilon proofreading subunit (antimutator effect) [1].
  • To study the role of these theta homologs, we have constructed an E. coli strain in which holE is replaced by the P1 homolog, hot [2].

High impact information on holE

  • Within the core (alpha-epsilon-theta), the alpha and epsilon subunits carry the DNA polymerase and 3' proofreading functions, respectively, while the precise function of theta is unclear. holE homologs are present in genomes of other enterobacteriae, suggestive of a conserved function [2].


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