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Gene Review:

selB - selenocysteinyl-tRNA-specific translation...

Escherichia coli UTI89

Thanbichler, M. et al., Mizutani, T. et al., Gr??be, T. et al.

Mizutani, Tanabe, Yamada,

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Disease relevance of selB

GrdB could be heterologously produced in Escherichia coli with coexpression of selB and selC from E. acidaminophilum for selenocysteine insertion [1].

High impact information on selB

In bacteria, these elements are positioned within the reading frame of selenoprotein mRNAs immediately downstream of the triplet coding for selenocysteine, and they tether a complex of the selenocysteine-specific elongation factor SelB, GTP and selenocysteyl-tRNA(Sec) to the site of UGA decoding [2].
A G.U base pair in the eukaryotic selenocysteine tRNA is important for interaction with SePF, the putative selenocysteine-specific elongation factor [3].

References

Peroxidase activity of selenoprotein GrdB of glycine reductase and stabilisation of its integrity by components of proprotein GrdE from Eubacterium acidaminophilum. Gr??be, T., Reuter, M., Gursinsky, T., S??hling, B., Andreesen, J.R. Arch. Microbiol. (2007) [Pubmed]
The function of SECIS RNA in translational control of gene expression in Escherichia coli. Thanbichler, M., Böck, A. EMBO J. (2002) [Pubmed]
A G.U base pair in the eukaryotic selenocysteine tRNA is important for interaction with SePF, the putative selenocysteine-specific elongation factor. Mizutani, T., Tanabe, K., Yamada, K. FEBS Lett. (1998) [Pubmed]

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