Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

aplnr-a - apelin receptor

Xenopus laevis

Synonyms: X-msr, XAngio1, Xmsr, agtrl1, agtrl1-A, ...

Inui, M. et al., Baltzinger, M. et al.

Baltzinger, Mager-Heckel, Remy,

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High impact information on agtrl1

XlFli morpholino had similar effects to Xapelin and Xmsr morpholinos on cardiac differentiation, suggesting an unexpected potential relationship between the endothelium and cardiac differentiation [1].
Xenopus preproapelin (Xpreproapelin) was isolated and its mRNA localized to the region around the presumptive blood vessels, which are overlapping or adjacent to those expressing Xmsr, the Xenopus homologue of APJ [1].
Forced expression of constitutive active Galphai rescued the phenotypes of Xmsr morpholino-injected embryos, indicating that the i/o type of G protein alpha subunit acts downstream of Xmsr [1].
Ventrally injected embryos show a posteriorization of the cells having received the message together with ectopic endothelial cell differentiation as revealed by the accumulation of X-msr transcripts [2].

References

Xapelin and Xmsr are required for cardiovascular development in Xenopus laevis. Inui, M., Fukui, A., Ito, Y., Asashima, M. Dev. Biol. (2006) [Pubmed]
Xl erg: expression pattern and overexpression during development plead for a role in endothelial cell differentiation. Baltzinger, M., Mager-Heckel, A.M., Remy, P. Dev. Dyn. (1999) [Pubmed]

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